A protein modifier called ubiquitin (UB) controls a variety of vital cellular functions. The E1 enzyme activates UB's C-terminal carboxylate to start the process of UB's transfer through the E1-E2-E3 cascade onto target proteins. The ubiquitin is attached to the E1 enzyme by a thioester bond during an ATP-dependent reaction, and this enzyme serves as the activating enzyme. The ubiquitin is transferred from the E1 enzyme to the conjugating E2 enzyme. The E3 enzyme, also known as the ubiquitin ligase, catalyzes the transfer of ubiquitin to the target protein (also known as the substrate) by forming an isopeptide bond.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V73115 | UC-764864 | 278806-03-4 | UC-764864 is a UBE2N inhibitor. |
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V51002 | WAY-608248 | 308297-79-2 | Skp2 inhibitor |
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V73092 | WSB1 Degrader 1 | 2306039-66-5 | WSB1 Degrader 1 is a potent orally bioactive WSB1 (WD repeat and SOCS box-containing 1) degrader. |