The farnesoid X receptor (FXR) is a nuclear receptor superfamily member and ligand-activated transcription factor. By binding to DNA as a monomer or a heterodimer with the common NR partner, retinoid x receptor (RXR), to FXR response elements, FXR controls the expression of numerous genes. The FXR and FXR genes are the two recognized FXR genes.
FXR is primarily expressed in the liver and small intestine, where it is critical for the metabolism of bile acids, lipids, and glucose. FXR regulates bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, as well as playing a significant role in intestinal bacterial growth and liver regeneration through its specific target genes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V78572 | XJ02862-S2 | XJ02862-S2 has good FXR agonistic activity. | |
|
V81777 | ZLY28 | ZLY28 is a first-in-class gut-restricted dual modulator of FXR and FABP1 with oral activity. | |
|
V86290 | β-FXR antagonist 1 | 2295804-92-9 |
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