Glucokinase

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate.Humans and the majority of other vertebrates have cells in their liver, pancreas, gut, and brain that contain glucokinase. It functions as a glucose sensor in each of these organs, signaling changes in metabolism or cell function in response to rising or falling blood glucose levels, such as those that happen after meals or during fasting. Since glucosekinase has a lower affinity for glucose than the other hexokinases do and concentrates its activity in a small number of cell types, the other three hexokinases are more crucial glucose preparers for most tissues' and organs' glycolysis and glycogen synthesis.Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

Glucokinase related products

Cat No.	Product Name	CAS No.	Product Description
V97475	2'-Rhamnoechinacoside	1422390-59-7	2'-Rhamnoechinacoside (Michelioside A), a phenolic alcohol glycoside, is an α-glucosidase inhibitor with antitumor activity from Phlomis stewartii.
V98131	ADP-specific glucokinase, pyrococcus furiosus	173585-07-4	ADP-specific glucokinase pyrococcus furiosus is an ADP-specific glucokinase expressed in a thermophilic archaeon.
V98144	ADP-Specific glucokinase, thermococcus litoralis		ADP-Specific glucokinase, thermococcus litoralis is an ADP-specific glucokinase expressed in thermophilic archaea.
V93961	Afegostat TFA	1084896-50-3	Afegostat TFA is a pharmacological chaperone that binds with high affinity, specificity, and reversibility to acid β-glucosidase (GCase) in the endoplasmic reticulum (ER).
V2904	AMG-3969	1361224-53-4	AMG-3969 is a potent, novelandmetabolically stabledisruptor of glucokinase-glucokinase regulatory protein interaction (GK-GKRP) with IC50of 4 nM.
V76979	GKA50 quarterhydrate		GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM).
V100422	GLS1 Inhibitor-1	1832646-52-2	GLS1 inhibitor-1 (Compound 27) is an oral glutaminase 1 (GLS1) inhibitor with IC50 of 0.021 μM.
V85141	Glucocerebrosidase-IN-2	851185-20-1
V97176	GSTP1-1 inhibitor 2		GSTP1-1 inhibitor 2 (compound 5g) is a hGSTP1-1 (glutathione transferase P1-1) inhibitor with IC50 value of 12.2 μM.
V25611	MK-0941 mesylate	1137916-97-2	MK-0941 mesylate, the mesylate salt ofMK0941, is a novel, orally bioactive and allosteric glucokinase activator (GKA) with anti-diabetic effects.
V78884	Mortatarin F		Mortatarin F (Compound 1) is a glucosidase inhibitor (antagonist) with IC50 of 8.7 μM.
V78908	Mortatarin G	2477746-26-0	Mortatarin G (compound 3) is a prenylated flavonoid that can be extracted from mulberry leaves.
V4556	PF-04991532	1215197-37-7	PF-04991532 is a novel, potent, hepatoselectiveglucokinaseactivator withEC50of 80 and 100 nM in human and rat, respectively.
V13883	RO 28-1675 (Ro 0281675)	300353-13-3	Ro 28-1675 (Ro-0281675) is a novel, potent and allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM.
V96896	SX29		SX29 is an orally active noncompetitive α-glucosidase inhibitor with IC50 of 2.12 μM.
V79743	Uvagrandol		Uvagrandol effectively inhibits α-glucosidase and porcine lipase (IC50= 15.2 μM and 11.2 μM, respectively).
V51000	WAY-320081	66780-67-4	glucokinase activator; HSP90 inhibitor
V96830	WXC-25		WXC-25 is an α-glucosidase inhibitor with IC50 value of 2.02 μM.
V79295	α-Amylase/α-Glucosidase-IN-3		α-Amylase/α-Glucosidase-IN-3 (Compound 17) is a dual α-Amylase/α-Glucosidase inhibitor (antagonist) with IC50 s of 0.70 μM and 1.10 μM.
V81782	α-Amylase/α-Glucosidase-IN-4		α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual (bifunctional) inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases), with IC50s of 0.15 μM and 1.10 μM respectively.