HIFs (Hypoxia-inducible factors) are transcription factors that react to variations in the amount of oxygen available to cells, more specifically, to reductions in oxygen, or hypoxia. The effects of hypoxia, a condition of low oxygen concentration, on the cell are mediated by the HIF signaling cascade. Oftentimes, hypoxia prevents cells from differentiating. However, hypoxia encourages the growth of blood vessels and is crucial for the development of a vascular system in both cancer tumors and embryos.Additionally, the hypoxia in wounds encourages keratinocyte migration and epithelium repair. HIFs are essential to development in general. HIF-1 gene deletion in mammals causes perinatal death. It has been demonstrated that HIF-1 is essential for chondrocyte survival and enables the cells to adapt to low oxygen environments in the growth plates of bones. Human metabolism is controlled in large part by HIF. A number of medications that function as selective HIF prolyl hydroxylase inhibitors have recently been created.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81522 | TAT-cyclo-CLLFVY TFA | TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of HIF-1 heterodimerization that can inhibit hypoxia signaling in cancer cells. | |
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V51621 | TRC-160334 | 1293289-69-6 | TRC160334 is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. |
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V5246 | Vadadustat (PG-1016548; AKB-6548) | 1000025-07-9 | Vadadustat (formerly AKB-6548;PG-1016548; B-506;AKB6548;PG1016548;Vafseo) is a novel, potent, titratable and orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with the potential for the treatment of anemia. |
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V51624 | Verucopeptin | 138067-14-8 | Verucopeptin is a potent activator of HIF-1 (IC50=0.22 μM) and can reduce the expression of HIF-1 target genes and the expression level of HIF-1α. |
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V51004 | WAY-325641 | 869354-47-2 | HIV-1 integrase inhibitor |
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V73833 | Zifcasiran sodium (ADS-007 sodium; ARO HIF2 sodium) | 2437257-12-8 | Zifcasiran sodium is a hypoxia-inducible factor (HIF) synthesis inhibitor and displays anti-tumor activity and may be utilized in the study of advanced renal cell carcinoma. |
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