LXRs (Liver X Receptor and ) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. As oxysterol-activated transcription factors, LXRs promote the coordinated mobilization of extra cholesterol from cells and the body by upregulating a group of genes. The LXRs, like other nuclear receptors, have anti-inflammatory properties. They prevent nuclear factor-B, activating protein-1, and other transcription factors from signaling-dependently inducing pro-inflammatory genes.
The liver, kidney, macrophages, and adipose tissue are among the tissues with the highest levels of LXR expression. However, LXR expression is pervasive. A growing body of research indicates that selective LXR agonists can mitigate the high triglyceride production that results from activating LXR, which is primarily expressed in the liver.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1853 | T0901317 (T-1317) | 293754-55-9 | T0901317 (formerly known as T-1317 or TO-091317 or TO 901317)is a potentand selective liver X receptor (LXR) agonist for multiple targets, which has EC50 values of 20 nM and 5 μM for LXRα and FXR, respectively. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
