Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69747 | IACS-15414 | 2411321-29-2 | IACS-15414 is an orally bioactive SHP2 inhibitor (antagonist) with IC50 of 122 nM. |
|
V84557 | Icerguastat Carbonate (Sephin1 Carbonate; IFB-088 Carbonate) | 1883549-35-6 | |
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V22435 | Idoxuridine | 54-42-2 | Idoxuridine (IdUrd; 5-Iodo-2′-deoxyuridine; 5-IUdR) is a potent anti-herpesvirus antiviral and anticancer drug. |
|
V25175 | INVIVO-4823 | 1908414-82-3 | INVIVO-4823, formerly known as LMPTP inhibitor1; is a potent inhibitor of the low-molecular-weight tyrosine phosphatase (LMPTP). |
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V80417 | ITH12711 | ITH12711 is a PP2A ligand. | |
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V79145 | KLH45b | KLH45b is an inhibitor (blocker/antagonist) of DDHD2. | |
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V76841 | L-690330 hydrate | L-690330 hydrate is a competitive inositol monophosphatase (IMPase) inhibitor (antagonist) with Kis of 0.27 μM and 0.19 μM for recombinant human and bovine IMPase, and Ki for human and bovine forebrain cortex IMPase. | |
|
V29922 | Licoflavone A | 61153-77-3 | Licoflavone A is a flavonoid obtained from licorice root and inhibits the activity of tyrosine phosphatase 1B (PTP1B) with IC50 of 54.5 μM. |
|
V2954 | LMPTP INHIBITOR 1 dihydrochloride | 2310135-46-5 | LMPTP INHIBITOR 1 is a novel and selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP)(IC50 = 0.8 μM LMPTP-A). |
|
V73302 | LMPTP inhibitor 1 hydrochloride | 2310135-38-5 | LMPTP inhibitor 1 HCl is a selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor that can inhibit the activity of LMPTP-A with IC50 of 0.8 μM. |
|
V69745 | LYP-IN-1 | 1404436-51-6 | LYP-IN-1 is a specific and specific LYP inhibitor (antagonist) with Ki and IC50s of 110 nM and 0.259 μM respectively. |
|
V76804 | LYP-IN-3 | LYP-IN-3 (compound D34) is a selective inhibitor (Ki=0.93 μM) of lymphoid tyrosine phosphatase (LYP), which regulates the T cell receptor (TCR) signaling pathway in tumor progression. | |
|
V78413 | LYP-IN-4 | LYP-IN-4 (compound D14) is a reversible and specific inhibitor of lymphoid tyrosine phosphatase (LYP) (Ki=1.34 μM, IC50=3.52μM). | |
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V73330 | M5N36 | 2832887-40-6 | M5N36 is a potent and specific Cdc25C inhibitor (antagonist) with IC50s of 0.15, 0.19 and 0.06 µM for Cdc25A, Cdc25B and Cdc25C respectively. |
|
V73350 | Methyl pseudolarate B | 82508-34-7 | Methyl pseudolarate B is a natural diterpenoid and a protein tyrosine phosphatase 1B (PTP1B) (Phosphatase) inhibitor (antagonist) with IC50 of 10.9 μM. |
|
V85053 | ML120 analog 1 | 445426-74-4 | |
|
V73288 | MLS-0437605 | 862975-18-6 | MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor (antagonist) with IC50 of 3.7 μM. |
|
V73290 | MY10 | 2204270-73-3 | MY10 is a potent and orally bioactive receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. |
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V73307 | MY33-3 | 2204280-41-9 | MY33-3 is a potent and specific inhibitor of protein tyrosine phosphatase RPTPβ/ζ with IC50 of ~0.1 μM. |
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V73284 | NAZ2329 | 2809469-05-2 | NAZ2329 is the first cell-permeable (penetrable) inhibitor of the R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), which allosterically and preferentially inhibits PTPRZ (IC50 for hPTPRZ1 = 7.5 µM) and PTPRG ( hPTPRG IC50 = 4.8 µM). |
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