Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73353 | NC1 | 445406-82-6 | NC1 is a noncompetitive allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor (antagonist) with a Ki of 4.3 μM. |
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V4755 | NSC-663284 | 383907-43-5 | NSC-663284 (also known as SPS-8I1; DA3003-1) is a novel and potent inhibitor of the Cdc25 dual specificity phosphatases and SETD8with anticancer activity. |
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V5022 | NSC117079 | 500363-63-3 | NSC117079 is a novel and potent PHLPP1 (Pleckstrin homology domain and leucine-rich repeat protein phosphatase 1) inhibitor. |
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V73352 | NTPDase-IN-1 | 2962812-29-7 | NTPDase-IN-1 (Compound 5a) is a selective NTPDase inhibitor (antagonist) with IC50s of 0.05, 0.23 and 0.54 µM for h-NTPDase-1/-2/-8, respectively. |
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V73328 | NTPDase-IN-2 | 2883147-47-3 | NTPDase-IN-2 (Compound 5g) is a selective NTPDase inhibitor (antagonist) with IC50s of 0.04 and 2.27 µM for h-NTPDase-2/-8, respectively. |
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V73314 | NTPDase-IN-3 | 2883147-45-1 | NTPDase-IN-3 (Compound 5e) is an NTPDase inhibitor (antagonist) with IC50s of 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). |
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V73300 | PFKFB3-IN-2 | 794552-84-4 | PFKFB3-IN-2 is a fructose-6-phosphate-2kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor. |
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V73291 | PGAM1-IN-1 | 2438637-65-9 | PGAM1-IN-1 is a potent inhibitor of phosphoglycerate mutase 1 (PGAM1) with IC50 of 6.4 μM. |
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V73295 | PGAM1-IN-2 | 2438637-66-0 | PGAM1-IN-2 is a potent inhibitor of phosphoglycerate mutase 1 (PGAM1) with IC50 of 2.1 μM. |
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V57066 | Phosphatase Binder-1 | 2456385-41-2 | Phosphatase Binder-1 (comppund i-196) provides a bifunctional compound that effectively dephosphorylates certain phosphate-activated target proteins. |
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V1983 | Pimecrolimus (ASM 981) | 137071-32-0 | Pimecrolimus (formerly known as ASM-981; SDZ-ASM981) is an ascomycin analog which acts asan immunomodulating agent and is used in the treatment of atopic dermatitis. |
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V73340 | PLAP-IN-1 | 2857113-78-9 | PLAP-IN-1 is a potent (IC50 = 32 nM) and selective PLAP inhibitor (antagonist) with no significant inhibitory effect on tissue non-specific alkaline phosphatase (TNAP) activity. |
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V73324 | PP5-IN-1 | 1022417-69-1 | PP5-IN-1 (Compound P053) is a competitive serine/threonine protein phosphatase-5 (PP5) inhibitor that binds to its catalytic domain and causes apoptosis in renal cancer cells. |
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V85022 | PRL-IN-1 | 331431-75-5 | |
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V73306 | PROTAC PTPN2 degrader-1 | 2655638-07-4 | PROTAC PTPN2 degrader-1 (example compound 77) is a potent PTPN2 degrader. |
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V73316 | PROTAC PTPN2 degrader-2 | 2912307-38-9 | PROTAC PTPN2 degrader-2 (example 187B) is a potent PTPN2 degrader with potential for studying cancer or metabolic diseases. |
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V73346 | PROTAC PTPN2 degrader-2 TFA | 2912307-39-0 | PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent PTPN2 degrader with potential for studying cancer or metabolic diseases. |
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V69751 | PTP Inhibitor IV | 329317-98-8 | PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity, 50 at 5.21 μM. |
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V2859 | PTP1B-IN-1 | 612530-44-6 | PTP1B-IN-1 is a potent and new class of inhibitor of protein tyrosine phosphatase-1B (PTP1B) with IC50 of 1.6 mM; Itincorporates the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template that was identified throughstructure-based design. |
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V73341 | PTP1B-IN-13 | 650621-20-8 | PTP1B-IN-13 is a selective PTP1B inhibitor that targets the allosteric site with IC50 of 1.59 μM. |
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