Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V56170 | Roflumilast-d4 N-Oxide (Roflumilast d4 (N-oxide)) | 1794760-31-8 | Roflumilast-d4 N-Oxide is the deuterium labelled form of Roflumilast. |
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V72082 | S32826 | 1096770-84-1 | S32826 is a potent autotaxin inhibitor (antagonist) with IC50 of 8.8 nM. |
|
V4198 | Sildenafil | 139755-83-2 | Sildenafil (formerly UK92480; UK-92480;Trade name: Revatio), the free base form of Sildenafil, is a potentandselective inhibitor of phosphodiesterase type 5 (PDE5) withIC50of 5.22 nM. |
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V72050 | Sildenafil-d3 (UK-92480-d3) | 1126745-90-1 | Sildenafil-d3 is deuterium-labeled sildenafil. |
|
V72087 | Sildenafil-d3N-1 (UK-92480-d3N-1) | 1126745-87-6 | Sildenafil-d3-1 (UK-92480-d3-1) is deuterium-labeled sildenafil. |
|
V69110 | Sp-cAMPS sodium salt | 142439-95-0 | Sp-cAMPS sodium salt, a cAMP analog, is a potent cAMP-dependent activator of PKA I and PKA II. |
|
V69116 | Sp-cAMPS triethylamine | 93602-66-5 | Sp-cAMPS triethylamine, a cAMP analog, is a potent cAMP-dependent activator of PKA I and PKA II. |
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V72065 | Tadalafil-d3 (IC-351-d3) | 960226-55-5 | Tadalafil-d3 is the deuterium labelled form of Nortadalafil. |
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V72044 | Theodrenaline hydrochloride ((±)-Theodrenaline hydrochloride) | 2572-61-4 | Theodrenaline HCl is a cardiotonic agent and is often mixed with Cafedrine in proportion to form Akrinor, which has a blood pressure lowering effect. |
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V72026 | Thioquinapiperifil dihydrochloride (KF31327) | 204077-66-7 | Thioquinapiperifil di-HCl (KF31327) is a specific, noncompetitive (IC50 of 0.074 nM) inhibitor of phosphodiesterase (PDE-5) for studies of sexual maturation. |
|
V16347 | THPP-1 | 1257051-63-0 | THPP-1 is a novel, potent and orally bioavailable PDE10A (phosphodiesterase 10A) inhibitor withKi values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. |
|
V72016 | TMX-4100 | 2367619-63-2 | TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. |
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V72085 | Toddacumalone | 139750-79-1 | Toddacoumalone is a natural phosphodiesterase 4 (PDE4) inhibitor (antagonist) with moderate potency and imperfect active molecule-like properties. |
|
V72034 | TPN729 | 936951-20-1 | TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor (antagonist) with IC50 of 2.28 nM. |
|
V72036 | TPN729MA (TPN729 maleate) | 1422955-52-9 | TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor (antagonist) with IC50 of 2.28 nM. |
|
V72011 | Trequinsin hydrochloride (HL 725) | 78416-81-6 | Trequinsin HCl (HL 725) is a potent inhibitor of platelet CAMP phosphodiesterase (PDE) with IC50 of 0.25 nM. |
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V72045 | Udenafil-d7 (Udenafil d7) | 1175992-76-3 | Udenafil-d7 is the deuterium labelled form of Udenafil. |
|
V31439 | Vardenafil HCl | 224785-91-5 | Vardenafil HCl, also known as BAY 38-9456 HCl,is a novel and potent PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
|
V27984 | Vesnarinone (OPC8212) | 81840-15-5 | Vesnarinone (OPC-8212) is a quinolinone-based cardiotonic agent, acting as a mixed phosphodiesterase 3 (PDE3) inhibitor and ion-channel modifier with modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. |
|
V72037 | Vinpocetine-d5 (vinpocetine d5) | 2734920-39-7 | Vinpocetine-d5 is the deuterium labelled form of Vinpocetine. |
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