Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V72052 | Norbraylin (Norbraylin) | 60796-64-7 | Norbraylin is a natural prenylated coumarin and a PDE4D2 inhibitor (antagonist) with IC50 of 7.15 μM. |
|
V91022 | Obscurolide A1 | 144397-99-9 | Obscurolide A1 is a phosphodiesterase (PDE) inhibitor (IC50=8 mM) obtained from the culture medium of Streptomyces viridochromogenes. |
|
V100262 | OPB-171775 | 2131210-15-4 | OPB-171775 is a molecular glue that forms a ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). |
|
V72093 | PAT-347 | 1689554-51-5 | PAT-347 is an Autotaxin (ATX) inhibitor. |
|
V92293 | PDE-IN-3 | 56344-53-7 | PDE-IN-3 (compound 23) is a phosphodiesterase (PDE) inhibitor with IC50 of 260 μM. |
|
V72035 | PDE1-IN-3 | 2370966-46-2 | PDE1-IN-3, compound 4 (WO2019156861), is a selective inhibitor of human phosphodiesterase 1 (PDE1). |
|
V78586 | PDE1-IN-5 | PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50= 15 nM). | |
|
V87673 | PDE1-IN-7 | 3027833-49-1 | PDE1-IN-7 (Compound 13h) is a selective inhibitor of bPDE1 (IC50=10 nM). |
|
V104899 | PDE1-IN-8 | PDE1-IN-8 (Compound 3f) is an inhibitor of PDE1 with IC50 of 11 nM. | |
|
V72097 | PDE10-IN-2 | 1516895-53-6 | PDE10-IN-2 is a PDE10 inhibitor (antagonist) with IC50≦0.01 μM. |
|
V76651 | PDE10A-IN-2 hydrochloride | PDE10A-IN-2 HCl is a specific, orally bioactive inhibitor of phosphodiesterase 10A (PDE10A) with IC50 of 2.8 nM. | |
|
V103555 | PDE10A-IN-3 | 1006889-85-5 | PDE10A-IN-3 (Compound 8a) is a phosphodiesterase 10A (PDE10A) inhibitor. |
|
V79536 | PDE11A4-IN-1 | 3027607-92-4 | PDE11A4-IN-1 (compound 23b) is a potent and specific PDE11A4 inhibitor (antagonist) with IC50 of 12 nM. |
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V94404 | PDE11A4-IN-2 | PDE11A4-IN-2 (compound 4g) is an orally bioavailable, brain-penetrant, selective and potent PDE11A4 inhibitor. | |
|
V72047 | PDE2A-IN-1 | 2648290-28-0 | PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor (antagonist) with IC50 of 1.3 nM. |
|
V83382 | PDE3B-IN-1 | ||
|
V72092 | PDE4-IN-12 | 2901084-32-8 | PDE4-IN-12 is a potent pan-PDE4 inhibitor (antagonist) with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI 2.71 and 4.27, respectively). |
|
V79934 | PDE4-IN-13 | PDE4-IN-13 is a PDE4 inhibitor (antagonist) with IC50 of 1.56 μM. | |
|
V72053 | PDE4-IN-14 | 2231329-25-0 | PDE4-IN-14 (Compound 1) is a PDE4 inhibitor that may be utilized in the study of PDE4-related diseases (such as inflammatory and immune diseases, cancer, and metabolic diseases, etc. |
|
V92280 | PDE4-IN-16 | 223500-15-0 | PDE4-IN-16 (compound 27) is a PDE4 inhibitor with IC50 of 3.61 μM. |
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