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Phosphodiesterase(PDE)

Phosphodiesterase(PDE)

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.

Phosphodiesterase(PDE) related products

Structure Cat No. Product Name CAS No. Product Description
PDE4-IN-17 V87669 PDE4-IN-17 PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor.
PDE4-IN-19 V97888 PDE4-IN-19 3042879-82-0 PDE4-IN-19 (Compound 1) is a PDE4 inhibitor with IC50 values of <10 nM and 10-100 nM for PDE4B1 and PDE4D3, respectively.
PDE4-IN-21 V94050 PDE4-IN-21 PDE4-IN-21 (Compound L19) is a potent PDE4 inhibitor with IC50 of 0.48 μM.
PDE4-IN-24 V104914 PDE4-IN-24 PDE4-IN-24 (compound 14h) is a potent inhibitor of PDE4D with IC50 of 0.57 nM, showing >4100-fold selectivity over other PDE families.
PDE4-IN-25 V107786 PDE4-IN-25 346440-86-6 PDE4-IN-25 (Compound 12) is a potent PDE4 inhibitor with IC50 of 0.1 μM.
PDE4-IN-3 V72090 PDE4-IN-3 2755687-49-9 PDE4-IN-3 is a novel orally bioactive PDE4 inhibitor (antagonist) with strong inhibitory affinity (b>IC50 = 4.2 nM).
PDE4-IN-4 V70519 PDE4-IN-4 1793069-00-7 PDE4-IN-4 is an M3 antagonist (pIC50 = 10.2) and PDE4 inhibitor (pIC50 = 8.8) used in inhalation studies in pulmonary diseases.
PDE4-IN-5 V72066 PDE4-IN-5 2768626-06-6 PDE4-IN-5 (compound 33a) is a potent and specific PDE4 inhibitor (IC50=3.1 nM).
PDE4B-IN-2 V72013 PDE4B-IN-2 915082-52-9 PDE4B-IN-2 is an orally bioactive, selective PDE4B inhibitor (antagonist) with IC50 of 15 nM.
PDE4B-IN-3 V72015 PDE4B-IN-3 2819779-01-4 PDE4B-IN-3 is a potent PDE4B inhibitor (antagonist) with IC50 of 0.94 μM.
PDE4B/7A-IN-1 V72062 PDE4B/7A-IN-1 2511632-25-8 1A/5-hydroxynitrile rubber 7 receptor antagonist (5-HT1 aki = 8 nm, kb= 0.04 nm; 5-nitrile rubber 7K I = 451 nm, kb= 460 nm), with PDE4B/PDE7A inhibitory activity (PDE4B ic50= 80.4 μM; Pde7a chip 50= 151.3 μM).
PDE4B/7A-IN-2 V72058 PDE4B/7A-IN-2 2511632-55-4 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki=8 nM, Kb=0.04 nM; 5-HT7 Ki=451 nM, Kb=460 nM) has PDE4B/PDE7A inhibitory activity (PDE4B IC50=80.4μM ; PDE7A IC50=151.3μM), its antidepressant-like effect is stronger than that of escitalopram, which is the reference active molecule.
PDE4B/D-IN-1 V102231 PDE4B/D-IN-1 3034683-55-8 PDE4B/D-IN-1 (Example 8) is a potent inhibitor of PDE4B with IC50 values of 0.07 nM and 0.09 nM for PDE4B2 and PDE4D, respectively.
PDE4B/D-IN-2 V102238 PDE4B/D-IN-2 3034683-66-1 PDE4B/D-IN-2 (Example 19) is a potent inhibitor of PDE4 with IC50 values of 0.023 nM and 0.066 nM for PDE4B2 and PDE4D, respectively.
PDE4B/D-IN-3 V102230 PDE4B/D-IN-3 3034683-69-4 PDE4B/D-IN-3 (Example 22) is a potent inhibitor of PDE4 with IC50 values of 0.071 nM and 0.09 nM for PDE4B2 and PDE4D, respectively.
PDE4B/D-IN-4 V93762 PDE4B/D-IN-4 PDE4B/D-IN-4 (Compound 4p) is a potent inhibitor of PDE-4B and PDE-4D with IC50 of 5.50 nM and 6.81 nM, respectively.
PDE5-IN-10 V79800 PDE5-IN-10 PDE5-IN-10 (compound 4b) is a potent PDE5 inhibitor (antagonist) with IC50 of 20 nM.
PDE5-IN-11 V79793 PDE5-IN-11 PDE5-IN-11 is a potent PDE5 inhibitor (antagonist) with IC50 of 40 nM.
PDE5-IN-12 V87667 PDE5-IN-12 PDE5-IN-12 (compound 4h) is a potent phosphodiesterase 5 (PDE-5) inhibitor with IC50 of 22 nM.
PDE5-IN-13 V105054 PDE5-IN-13 PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC50 of 3 nM.
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