Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V12983 | W-7 HCl | 61714-27-0 | W-7 HCl is a novel, potent and selective calmodulin antagonist with antitumor activity. |
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V72029 | Yonkenafil (Tunodafil) | 804518-63-6 | Yonkenafil (Tunodafil) is a novel phosphodiesterase 5 (PDE5) inhibitor that is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. |
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V83235 | Z21090 (ZL40) | 2992690-71-6 | Z21090 (ZL40) is a novel PDE4 inhibitor with IC50 of 37.4 nM, may be used in the research of alcohol-related diseases. |
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V8408 | Zaprinast | 37762-06-4 | Zaprinast is apotentphosphodiesterase (PDE) inhibitor withselectivityfor PDE5, PDE6, PDE9 and PDE11 andIC₅₀ values of 0.76, 0.15, 29.0, and 12.0 μM, respectively. |
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V24190 | Zardaverine | 101975-10-4 | Zardaverine is a novel and selective PDE (Phosphodiesterase) 3/4 inhibitor with IC50 values of 0.5 uM and 0.8 uM respectively. |
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V72009 | Zatolmilast (BPN14770) | 1606974-33-7 | Zatolmilast (BPN14770) is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50s of 7.8 nM for PDE4D7 and 7.4 nM for PDE4D3. |
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V60039 | Siguazodan | 115344-47-3 | Siguazodan, also known as SKF 94836, is an orally active phosphodiesterase III (PDE-III) inhibitor. It's IC50 & Target is 117 nM. |
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