Serine (Ser) proteases are enzymes that catalyze the hydrolysis of specific peptide bonds in their substrates, and one of the amino acids in the enzyme's active site is always a serine. The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71894 | Dansyl-Glu-Gly-Arg-Chloromethylketone | 69024-84-6 | Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that can suppress serine/threonine proteases. |
|
V71911 | DCLK1-IN-2 | 2978517-43-8 | DCLK1-IN-2 (compound I-5) is a potent inhibitor of DCLK1 with IC50 of 171.3 nM. |
|
V84473 | DCLK1-IN-3 | ||
|
V84481 | DCLK1-IN-4 | ||
|
V71876 | Dim16 | 2743448-32-8 | Dim16 is a dual PCSK9/HMG-CoAR inhibitor (antagonist) with IC50 of 19 nM for PCSK9. |
|
V71861 | Ebronucimab (AK102) | 2304800-90-4 | Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells. |
|
V71891 | Endoproteinase Glu-C (V8 protease; Glu-C) | 137010-42-5 | Endoproteinase GluC (V8 protease) is a serine protease. |
|
V83229 | Enlicitide chloride (MK-0616) | 2407527-16-4 | Enlicitide chloride (MK-0616) is a novel and orally bioactive cyclic peptide-based PCSK9 inhibitor |
|
V71912 | Enteropeptidase (TMPRSS15) | 9014-74-8 | Enteropeptidase (TMPRSS15) is a type II transmembrane serine protease and a physiological activator of trypsinogen. |
|
V71866 | Feniralstat | 2166320-76-7 | Feniralstat is a pyrazole analogue, a potent kallikrein inhibitor (antagonist) with IC50 of 6.7 nM for human plasma kallikrein (pKal). |
|
V71869 | Flizasertib | 2268739-68-8 | Flizasertib is a serine/threonine kinase inhibitor. |
|
V71893 | Fluorescent Substrate for Subtillsin | 147471-56-5 | Fluorescent Substrate for Subtillsin may be utilized to detect the enzyme activity of Subtillsin. |
|
V71862 | Frovocimab (LY 3015014) | 1643672-70-1 | Frovocimab (LY 3015014) is a humanized IgG4 monoclonal antibody (mAb) that neutralizes PCSK9. |
|
V73406 | Galegenimab (FHTR 2163; RG 6147; RO 7171009) | 2403683-24-7 | Galegenimab (FHTR 2163; RG 6147; RO 7171009), an anti-HTRA1 antibody fragment. |
|
V71909 | GGACK | 65113-67-9 | GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase plasminogen activator (uPA). |
|
V71903 | HMB-Val-Ser-Leu-VE | 862891-04-1 | HMB-Val-Ser-Leu-VE is a prototype vinyl ester vinyl ester inhibitor. |
|
V73397 | Inclisiran (ALN-PCSsc) | 1639324-58-5 | Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that can inhibit PCSK-9 transcription. |
|
V71859 | Irucalantide | 1631160-47-8 | Irucalantide is a kallikrein inhibitor. |
|
V71863 | Lerodalcibep (LIB003) | 2250073-78-8 | Lerodalcibep (LIB003) is a recombinant fusion protein of PCSK9 binding domain (adnectin) and human serum albumin. |
|
V5056 | LSP-249 | 1801253-04-2 | LSP-249 (example 35), information from patent WO2016011209A1, is an inhibitor (blocker/antagonist) of plasma kallikrein, utilized in study/research of angioedema, with EC50 of less than 100 nM. |
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