Serine (Ser) proteases are enzymes that catalyze the hydrolysis of specific peptide bonds in their substrates, and one of the amino acids in the enzyme's active site is always a serine. The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71914 | SPC4061 | 1018108-22-9 | SPC4061 is an antisense nucleotide and a potent PCSK9 inhibitor. |
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V81424 | SPC4061 sodium | SPC4061 sodium is an antisense nucleotide and a potent PCSK9 inhibitor. | |
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V71905 | Suc-AAPA-pNA | 72682-69-0 | Suc-AAPA-pNA is a substrate of chymotrypsin Aα. |
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V71913 | Tafolecimab (IBI-306) | 2225109-03-3 | Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody (mAb) that specifically binds to PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the low-density lipoprotein receptor, thereby enhancing The clearance of LDL-C leads to a decrease in LDL-C levels. |
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V71877 | TAO Kinase inhibitor 2 | 850467-77-5 | TAO Kinase inhibitor 2 (Example 49) is a TAO kinase inhibitor (IC50=50-500 nM). |
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V51697 | Tilpisertib (GS-4875) | 2065153-41-3 | Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689). |
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V71883 | TMPRSS6-IN-1 | 2088415-78-3 | TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), which belongs to the TTSP family (a transmembrane serine protease). |
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V71872 | Tos-Gly-Pro-Lys-AMC | 128202-25-5 | Tos-Gly-Pro-Lys-AMC is a trypsin-like fluorescent peptide substrate. |
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V73399 | Trypsin Inhibitor, soybean | 9035-81-8 | Trypsin Inhibitor, soybean is a potent and reversible inhibitor of trypsin. |
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V71886 | UAMC-00050 | 2842774-51-8 | UAMC-00050 is a potent trypsin-like serine protease inhibitor. |
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V71857 | Urokinase (peptidolytic) (Urokinase; Urokinase-type plasminogen activator; Uronase; Win 22005; Win-Kinase) | 9039-53-6 | Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease and an inactive form (zymogen) of the serine protease plasmin. |
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V70219 | Vevorisertib (ARQ 751) | 1416775-46-6 | Vevorisertib (ARQ 751) is an orally bioactive, potent and specific pan-AKT serine/threonine kinase inhibitor of AKT1 (IC50=0.55 nM), AKT2 (IC50=0.81 nM) and AKT3 (IC50= 1.31 nM) is inhibitory. |
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V73408 | WNK1-IN-1 | 324022-39-1 | WNK1-IN-1 is a selective inhibitor of WNK1 with IC50 of 1.6 μM. |
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V3433 | WNK463 | 2012607-27-9 | WNK463 (NVP-WNK463) is a novel, potent and orally bioavailable pan-WNK-kinase inhibitor withIC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively. |
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V71880 | Z-Val-Gly-Arg-pNA | 78333-16-1 | Z-Val-Gly-Arg-pNA is a chromogenic substrate for urokinase. |
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V73278 | ZK824859 hydrochloride | 2436760-76-6 | ZK824859 HCl is an orally bioactive and selective urokinase-type plasminogen activator (uPA) inhibitor for human uPA, tPA and plasmin with IC50 of 79 nM, 1580 nM and 1330 nM respectively. |
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V71887 | α-Lytic protease (α-lytic protease; alphaLP) | 37288-76-9 | α-Lytic protease (alphaLP) is a serine endopeptidase. |
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