Thrombin is a Na+-activated, serine protease that is activated by activated Factor X's enzymatic cleavage of two sites on prothrombin. Two allosteric forms of thrombin, slow (S) and fast (F), are focused on procoagulant and anticoagulant activities, respectively.
By activating platelets, thrombin is the primary effector protease in primary hemostasis and is essential for secondary hemostasis. In addition to its well-known roles in hemostasis, thrombin also contributes to a number of biological and pathophysiologic processes that are not hemostatic, most of which are mediated by the activation of protease-activated receptors (PARs). Thrombin cleaves PAR-1, PAR-3, and PAR-4 whereas trypsin cleaves PAR-2. Additionally, thrombin is essential for the migration and metastasis of human cancer cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71925 | 15,16-Dihydrotanshindiol C (15,16-Dihydrotanshindiol C) | 891854-96-9 | 15,16-Dihydrotanshindiol C is a diterpenoid and a potent thrombin inhibitor. |
|
V94287 | Atecegatran TFA | 433937-75-8 | Artigatran TFA (AR-H067637 TFA) is an anticoagulant with selective direct thrombin inhibitory activity. |
|
V71920 | BAY 1217224 | 1639886-32-0 | BAY 1217224 is a neutral non-precursor inhibitor of Thrombin with good oral pharmacokinetics. |
|
V71924 | Dabigatran-13C6 (BIBR 953-13C6; BIBR 953ZW-13C6) | 1210608-88-0 | Dabigatran-13C6 is 13C (carbon 13)-labeled Dabigatran. |
|
V71927 | Dabigatran-d3 (BIBR 953-d3; BIBR 953ZW-d3) | 1246817-44-6 | Dabigatran-d3 is the deuterium labelled form of Dabigatran. |
|
V77109 | Dabigatran-d4 hydrochloride (Dabigatran D4 hydrochloride; BIBR-953-d4 hydrochloride) | Dabigatran-d4 ( HCl) is the deuterated form of Dabigatran. | |
|
V85751 | Dermatan sulphate sodium (Chondroitin B sulfate) | 54328-33-5 | |
|
V94230 | Efegatran di(hydrochloride) | 173006-83-2 | Efegatran (LY 294468) dihydrochloride is a thrombin inhibitor that inhibits platelet aggregation and exerts anticoagulant and antithrombotic effects. |
|
V87737 | FXIIa-IN-5 | FXIIa-IN-5 (Compound 4J) is an orally available, selective inhibitor of factor XIIa (FXIIa) with IC50 of 21 nM. | |
|
V71916 | Hirullin P18 | 131147-81-4 | Hirullin P18 is a potent thrombin inhibitor. |
|
V87738 | Idrabiotaparinux | 774531-07-6 | Idrabiotaparinux is a derivative of Idraparinux, a new synthetic anticoagulant that links the specific indirect factor Xa inhibitor Idraparinux to biotin. |
|
V93121 | LK-732 | 673485-33-1 | LK-732 is a thrombin inhibitor with anti-thrombotic effects and can be used in cardiovascular and cerebrovascular research. |
|
V87740 | Pirmagrel | 85691-74-3 | Pirmagrel is a thromboxane synthetase inhibitor that inhibits lipopolysaccharide-stimulated thromboxane secretion. |
|
V71928 | Rovunaptabin (ARC 183) | 145563-68-4 | Rovunaptabin (ARC 183) is a nucleic acid aptamer, a single-stranded DNA molecule consisting of 15 deoxynucleotides, forming a clear three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity. |
|
V71922 | Sar-Pro-Arg-pNA | 77695-30-8 | Sar-Pro-Arg-pNA is a chromogenic substrate for α-thrombin. |
|
V85847 | SAR107375 | 1184300-63-7 | |
|
V87736 | Sulodexide | 57821-29-1 | Sulodexide is an orally available glycosaminoglycan mixture consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). |
|
V71915 | TFLLRNPNDK-NH2 | 145229-90-9 | TFLLRNPNDK-NH2 is a biologically active peptide. |
|
V85052 | Thrombin inhibitor 11 | ||
|
V71923 | Thrombin inhibitor 6 | 1628224-94-1 | Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50= 1 nM). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
