Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases.Tyrosinases are the mammalian enzymes that initiate the production of melanin, the pigment that gives skin and hair their color, as well as the browning of fruits and vegetables after cell damage.
Tyrosinases are involved in pigmentation, wound healing, radiation protection, and the initial immune response. They are present in a variety of prokaryotes in addition to plants, fungi, arthropods, and mammals. The hydroxylation of monophenols and the oxidation of diphenols by tyrosinases results in quinones, which spontaneously polymerize to form melanin. Tyrosinases are crucial for wound healing and basic immune responses in plants, sponges, and a variety of invertebrates; they also aid in sclerotization in arthropods; and they shield DNA from UV ray damage in bacteria.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71942 | Isolindleyin | 87075-18-1 | Isolindleyin is a butyrophenone and a tyrosinase inhibitor (antagonist) with a Kd of 54.8 μM for human tyrosinase. |
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V71940 | Kojic acid dipalmitate (Kojic acid dipalmitate) | 79725-98-7 | Kojic acid dipalmitate (Kojic dipalmitate) is an analogue of Kojic acid, a fungal metabolite produced by Aspergillus, Acetobacter and Penicillium. |
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V71951 | Obtusifolin-2-O-glucoside | 120163-18-0 | Obtusifolin-2-O-glucoside (compound 7) is a tyrosinase inhibitor (IC50=9.2 μM), which can be extracted from Cassia seeds. |
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V71930 | p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) | 188640-63-3 | p-Ethynylphenylalanine HCl (4-Ethynyl-L-phenylalanine HCl) is a highly efficient, selective, reversible and competitive tryptophan hydroxylase (TPH) inhibitor (antagonist) with a Ki of 32.6 μM. |
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V71958 | Persiconin | 28978-03-2 | Persiconin is a tyrosinase inhibitor. |
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V15387 | SU 4942 | 76086-99-2 | SU-4942 is a tyrosine kinase signaling modulator. |
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V71948 | TNK2-IN-1 | 2574456-10-1 | TNK2-IN-1 is a TNK2 inhibitor. |
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V71934 | Tyrosinase (Polyphenol oxidase) | 9002-10-2 | Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls melanin production and is encoded by the TYR gene. |
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V71953 | Tyrosinase-IN-10 | 2873418-48-3 | Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor (antagonist) with IC50 of 1.6 μM that can inhibit tyrosinase activity in human melanoma cell lysates. |
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V71959 | Tyrosinase-IN-11 | 240797-64-2 | Tyrosinase-IN-11 is a potent tyrosinase inhibitor (antagonist) with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa respectively. |
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V71966 | Tyrosinase-IN-16 | 126651-85-2 | Tyrosinase-IN-16 (compound 19a) is a tyrosinase inhibitor (antagonist) with Ki=470 nM. |
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V71931 | Tyrosinase-IN-17 | 2427043-61-4 | Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable (penetrable) and non-cytotoxic inhibitor of Tyrosinase (the key enzyme that controls melanin production) (pIC50=4.99). |
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V85327 | Tyrosinase-IN-20 | 1024364-57-5 | |
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V84775 | Tyrosinase-IN-21 | ||
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V83898 | Tyrosinase-IN-22 (5-Chloro-2-mercaptobenzimidazole) | 25369-78-2 | |
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V83493 | Tyrosinase-IN-23 | ||
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V71960 | Tyrosinase-IN-7 | 2873418-52-9 | Tyrosinase-IN-7 is a potent tyrosinase inhibitor (antagonist) with IC50 of 1.57 µM. |
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V71957 | Viscumneoside III (mistletoe neoside III) | 118985-27-6 | Viscumneoside III is a dihydroflavone O-glycoside that can inhibit tyrosinase with IC50 of 0.5 mM. |
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V2594 | XMD16-5 | 1345098-78-3 | XMD16-5 is a novel and potent tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 16 nmol/L and 77 nmol/L for the D163E and R806Q mutations. |
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V2593 | XMD8-87 (ACK1-B19) | 1234480-46-6 | XMD8-87 (also known asACK1-B19) is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations. |
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