Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases.Tyrosinases are the mammalian enzymes that initiate the production of melanin, the pigment that gives skin and hair their color, as well as the browning of fruits and vegetables after cell damage.
Tyrosinases are involved in pigmentation, wound healing, radiation protection, and the initial immune response. They are present in a variety of prokaryotes in addition to plants, fungi, arthropods, and mammals. The hydroxylation of monophenols and the oxidation of diphenols by tyrosinases results in quinones, which spontaneously polymerize to form melanin. Tyrosinases are crucial for wound healing and basic immune responses in plants, sponges, and a variety of invertebrates; they also aid in sclerotization in arthropods; and they shield DNA from UV ray damage in bacteria.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71956 | Chlorogenic acid butyl ester | 132741-56-1 | Chlorogenic acid butyl ester is a caffeoylquinic acid, a potent melanogenesis inhibitor. |
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V99831 | Cyclo(l-Pro-d-Leu) | 36238-67-2 | Cyclo(l-Pro-d-Leu) (compound 11) is a collagenase inhibitor that can be extracted from R. atalantica and also exhibits slight tyrosinase inhibition. |
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V71941 | Cyclocommunol | 145643-96-5 | Cyclocommunol is an amyl flavonoid with antityrosinase and antiplatelet activity extracted from breadfruit. |
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V71964 | Diaminopropionoyl tripeptide-33 | 1199495-15-2 | Diaminopropionoyl tripeptide-33 is a biologically active peptide that has the effect of protecting skin cells from UVA-induced DNA damage and has been reported for use as a cosmetic ingredient. |
|
V71952 | Dodoviscin A | 1372527-25-7 | Dodoviscin A is a pigmentation-altering agent extracted from the aerial parts of Dodonaea viscosa. |
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V71965 | ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid | 57719-81-0 | ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is a tyrosinase inhibitor against melanin synthesis that can be extracted from Pteris fern. |
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V71947 | hTYR/AbTYR-IN-1 | 1625821-37-5 | hTYR/AbTYR-IN-1 (Compound 7) is a hTYR/AbTYR dual (bifunctional) inhibitor (antagonist) with IC50 of 5.4 μM and 3.52 μM for hTYR and AbTYR, respectively. |
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V107003 | Isobutylamido thiazolyl resorcinol | 1428450-95-6 | Isobutylamide thiazole resorcinol is a tyrosinase inhibitor that protects against UV-induced pigmentation. |
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V71942 | Isolindleyin | 87075-18-1 | Isolindleyin is a butyrophenone and a tyrosinase inhibitor (antagonist) with a Kd of 54.8 μM for human tyrosinase. |
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V71940 | Kojic acid dipalmitate (Kojic acid dipalmitate) | 79725-98-7 | Kojic acid dipalmitate (Kojic dipalmitate) is an analogue of Kojic acid, a fungal metabolite produced by Aspergillus, Acetobacter and Penicillium. |
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V87749 | Mycosporine 2 glycine | 149092-45-5 | Mycosporine 2 glycine is an inhibitor of tyrosinase-related protein 1 (TYRP1), binding to TYRP1 with good affinity and stability. |
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V71951 | Obtusifolin-2-O-glucoside | 120163-18-0 | Obtusifolin-2-O-glucoside (compound 7) is a tyrosinase inhibitor (IC50=9.2 μM), which can be extracted from Cassia seeds. |
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V71930 | p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) | 188640-63-3 | p-Ethynylphenylalanine HCl (4-Ethynyl-L-phenylalanine HCl) is a highly efficient, selective, reversible and competitive tryptophan hydroxylase (TPH) inhibitor (antagonist) with a Ki of 32.6 μM. |
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V71958 | Persiconin | 28978-03-2 | Persiconin is a tyrosinase inhibitor. |
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V97968 | Pseudostellarin G | 156525-71-2 | Pseudoasterol G is a natural cyclic octapeptide that has the activity of inhibiting tyrosinase and can inhibit the production of melanin. |
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V87751 | Sanggenon O | 101664-32-8 | Sanggenon O is a mushroom tyrosinase inhibitor isolated from Morus nigra with IC50 of 1.15 μM. |
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V105905 | Schisanhenol B | 102681-52-7 | Schisandrin B is one of the active ingredients of Schisandra chinensis. It is a tyrosinase inhibitor with good binding activity with PIK3CG and can be used in the study of heart failure. |
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V15387 | SU 4942 | 76086-99-2 | SU-4942 is a tyrosine kinase signaling modulator. |
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V105958 | Taraxinic acid | 75911-33-0 | Taraxacic acid is present in the roots of dandelion and red dandelion and is a tyrosinase inhibitor that inhibits tyrosinase activity in a dose-dependent manner, showing an inhibitory activity of about 54.5% at a concentration of 50 μg/mL. |
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V71948 | TNK2-IN-1 | 2574456-10-1 | TNK2-IN-1 is a TNK2 inhibitor. |
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