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Tyrosinase

Tyrosinase

Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases.Tyrosinases are the mammalian enzymes that initiate the production of melanin, the pigment that gives skin and hair their color, as well as the browning of fruits and vegetables after cell damage.

Tyrosinases are involved in pigmentation, wound healing, radiation protection, and the initial immune response. They are present in a variety of prokaryotes in addition to plants, fungi, arthropods, and mammals. The hydroxylation of monophenols and the oxidation of diphenols by tyrosinases results in quinones, which spontaneously polymerize to form melanin. Tyrosinases are crucial for wound healing and basic immune responses in plants, sponges, and a variety of invertebrates; they also aid in sclerotization in arthropods; and they shield DNA from UV ray damage in bacteria.

Tyrosinase related products

Structure Cat No. Product Name CAS No. Product Description
Tyrosinase (Polyphenol oxidase) V71934 Tyrosinase (Polyphenol oxidase) 9002-10-2 Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls melanin production and is encoded by the TYR gene.
Tyrosinase-IN-10 V71953 Tyrosinase-IN-10 2873418-48-3 Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor (antagonist) with IC50 of 1.6 μM that can inhibit tyrosinase activity in human melanoma cell lysates.
Tyrosinase-IN-11 V71959 Tyrosinase-IN-11 240797-64-2 Tyrosinase-IN-11 is a potent tyrosinase inhibitor (antagonist) with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa respectively.
Tyrosinase-IN-16 V71966 Tyrosinase-IN-16 126651-85-2 Tyrosinase-IN-16 (compound 19a) is a tyrosinase inhibitor (antagonist) with Ki=470 nM.
Tyrosinase-IN-17 V71931 Tyrosinase-IN-17 2427043-61-4 Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable (penetrable) and non-cytotoxic inhibitor of Tyrosinase (the key enzyme that controls melanin production) (pIC50=4.99).
Tyrosinase-IN-20 V85327 Tyrosinase-IN-20 1024364-57-5
Tyrosinase-IN-21 V84775 Tyrosinase-IN-21
Tyrosinase-IN-22 (5-Chloro-2-mercaptobenzimidazole) V83898 Tyrosinase-IN-22 (5-Chloro-2-mercaptobenzimidazole) 25369-78-2
Tyrosinase-IN-23 V83493 Tyrosinase-IN-23
Tyrosinase-IN-24 V87755 Tyrosinase-IN-24 Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor, which has inhibitory activity against mushroom tyrosinase.
Tyrosinase-IN-25 V87743 Tyrosinase-IN-25 Tyrosinase-IN-25 (compound 1l) is an inhibitor of tyrosinase and melanin biosynthesis in human melanoma cells.
Tyrosinase-IN-26 V87745 Tyrosinase-IN-26 Tyrosinase-IN-26 (compound 13) is a non-competitive tyrosinase inhibitor with IC50 of 68.86 µM.
Tyrosinase-IN-27 V87750 Tyrosinase-IN-27 2966803-96-1 Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC50: 0.88 μM) that can statically quench TYR.
Tyrosinase-IN-28 V87752 Tyrosinase-IN-28 Tyrosinase-IN-28 (Compound 4l) inhibits the activity of tyrosinase with IC50 of 72.55 μM by affecting substrate binding and enzyme catalysis.
Tyrosinase-IN-29 V87753 Tyrosinase-IN-29 408335-66-0 Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC50: 6.11 μM).
Tyrosinase-IN-31 V89024 Tyrosinase-IN-31 903206-81-5 Tyrosinase-IN-31 (compound 2-06) is a centrally targeted tyrosinase inhibitor (tyrosinase: monophenolase IC50=70.44 μM, diphenolase IC50=1.89 μM).
Tyrosinase-IN-32 V98844 Tyrosinase-IN-32 Tyrosinase-IN-32 (Compound 11) is a hydroxyamide alkaloid and mushroom tyrosinase inhibitor.
Tyrosinase-IN-33 V98916 Tyrosinase-IN-33 137058-21-0 Tyrosinase-IN-33 (compound 5), a pyridine compound, is a potent inhibitor of the diphenolase activity of mushroom tyrosinase.
Tyrosinase-IN-34 V98269 Tyrosinase-IN-34 Tyrosinase-IN-34 (compound 5a) is a human tyrosinase inhibitor (IC50: 3.5 μM) with the potential to control melanogenesis and pigmentation.
Tyrosinase-IN-35 V98274 Tyrosinase-IN-35 1613467-47-2 Tyrosinase-IN-35 (Compound 6g) is a human tyrosinase inhibitor (IC50: 2.09 μM), which is more potent than kojic acid (IC50: 16.38 μM).
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