Leukotrienes, lipoxins, and neuroprotectins are just a few of the eicosanoids and docosanoids that are produced as a result of the metabolism of arachidonic and docosahexaenoic acid by the family of enzymes known as lipoxygenases (LOXs). These enzymes are either involved in oxidative stress and cell death mechanisms or in cell protection, depending on the redox state of the cells and other milieu conditions. Lipoxygenases are lipid peroxidizing enzymes that may be targets for pharmacological treatment because they are involved in the pathogenesis of inflammatory and hyperproliferative diseases.
According to where arachidonate is oxygenated, lipoxygenases are categorized as 5-, 8-, 9-, 11-, 12-, and 15-LOX. 5-LOX, 8-LOX, 12-LOX, and 15-LOX are the most prevalent animal LOXs, whereas 5-LOX and 15-LOX are the most prevalent plant LOXs. When it comes to the production of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators, 5-LOX is the most prevalent isoform.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73494 | (-)-Dihydroguaiaretic acid | 124649-78-1 | (-)-Dihydroguaiaretic acid is a lipoxygenase (Lipoxygenase) inhibitor and has anti-oxidant effect. |
|
V87579 | (9S,13R)-12-Oxo phytodienoic acid | 71606-07-0 | (9S,13R)-12-Oxo phytodienoic acid is an isomer of 12-OPDA. |
|
V87583 | (±)15-HEDE | 77159-57-0 | (±)15-HEDE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE. |
|
V80079 | 12R-LOX-IN-2 | 3026677-37-9 | 12R-LOX-IN-2 (compound 7b) is an inhibitor (blocker/antagonist) of 12R-lipoxygenase (12R-LOX). |
|
V73512 | 15-LOX-1 inhibitor 1 | 2349374-37-2 | 15-LOX-1 inhibitor 1 is a potent 15-lipoxygenase-1 (15-LOX-1) inhibitor (antagonist) with IC50 of 0.19 μM. |
|
V87577 | 15-LOX-IN-1 | 15-LOX-IN-1 (Compound 7c) is a 15-LOX inhibitor with IC50 of 1.92 μM. | |
|
V2326 | 4-MMPB | 928853-86-5 | 4-MMPB is a selective lipoxygenase 15-lipoxygenase inhibitor with an IC50 value of 18 μM. |
|
V87571 | 17(S)-HpDHA | 123673-33-6 | 17(S)-HpDHA is the major product of the reaction of 15-Lipoxygenase (LOX) isozymes: h15-LOX-1 and h15-LOX-2 with docosahexaenoic acid (DHA). |
|
V73492 | 2-TEDC | 132465-10-2 | 2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC50s of 0.09 μM, 0.013 μM, and 0.5 μM, respectively. |
|
V73506 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid (3α-O-acetyl-11α-hydroxy-beta-boswellic acid) | 146019-25-2 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid is a 5-lipoxygenase (5-LO) inhibitor. |
|
V29713 | 4',5-Dihydroxyflavone | 6665-67-4 | 4',5-Dihydroxyflavone is a flavonoid analog acting as a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. |
|
V87578 | 5,6-Dehydroarachidonic acid | 58688-54-3 | 5,6-Dehydroarachidonic acid is a 5-lipoxygenase inhibitor that can inhibit the biosynthesis of leukotrienes. |
|
V73496 | 5,8,11-Eicosatriynoic acid (ETI) | 13488-22-7 | 5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks the biosynthesis of LTC4 in mastocytoma cells. |
|
V87570 | 5-Lipoxygenase blocking peptide | 5-Lipoxygenase blocking peptide (Human/rat 5-LO 130-149) is a specific sequence fragment of 5-lipoxygenase (5-LOX) and can be used to prepare antibodies against 5-LOX. | |
|
V73493 | 5-LOX-IN-1 | 55040-82-9 | 5-LOX-IN-1 (compound 2b) is an inhibitor (blocker/antagonist) of 5-Lipoxygenase (5-LOX) with IC50 of 2.3 μM. |
|
V73497 | 5-LOX-IN-3 | 1875061-47-4 | 5-LOX-IN-3 (Compound 14) is a 5-Lipoxygenase inhibitor (IC50= <1 μM). |
|
V77660 | 5-LOX-IN-5 | 5-LOX-IN-5 (Compound 29) is a 5-LOX inhibitor (IC50= 56 nM). | |
|
V98535 | 5-LOX/MAOs-IN-1 | 33865-93-9 | 5-LOX/MAOs-IN-1 (compound 3) is a 5-LOX/MAOs inhibitor and a potent free radical scavenger with antioxidant properties. |
|
V101103 | 5-LOX/sEH-IN-1 | 5-LOX/sEH-IN-1 (compound 8o) is a dual 5-LOX/sEH inhibitor with cardioprotective effects, with IC50 values of 3.05 μM and 2.20 nM, respectively, and can also inhibit the activity of COX-2 (IC50 = 10.50 μM). | |
|
V73491 | ALOX15-IN-1 | 2764818-24-6 | ALOX15-IN-1 (compound 8b) is a potent and specific inhibitor of rabbit and human ALOX15 linoleate oxygenase activity against ALOX15 orthologs linoleic acid (LA) and arachidonic acid. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
