The mammalian nicotinamide adenine dinucleotide (NAD+) synthetic salvage pathway uses nicotinamide phosphoribosyltransferase (NAMPT) as the rate-limiting enzyme to catalyze the conversion of nicotinamide (NAM) and phosphoribosyl-pyrophosphates to nicotinamide mononucleotide (NMN). NAMPT is found in two different forms: extracellular (eNAMPT) and intracellular (iNAMPT).
Brown adipose tissue (BAT), liver, and kidney have high iNAMPT levels; white adipose tissue (WAT), lung, spleen, testes, and skeletal muscle have intermediate levels; and the brain and pancreas have undetectable iNAMPT levels. The release of eNAMPT into plasma, which is thought to result from post-translational modification of iNAMPT, is primarily caused by adipose tissue. There, it catalyzes the synthesis of NMN. Although eNAMPT has been reported to function as a cytokine with numerous roles in physiology and pathology, intracellular NAMPT is a key enzyme in controlling NAD metabolism. Cancer and other metabolic and inflammatory diseases have been linked to circulating eNAMPT.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V85413 | Anticancer agent 177 | ||
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V84331 | Antitumor agent-136 | 2484876-94-8 | |
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V0961 | GMX1778 (CHS828) | 200484-11-3 | GMX1778 (GMX 1778;CHS828; GMX-1778;CHS-828) is a potent and selective/specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with potential antitumor activity. |
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V0098 | GNE-617 | 1362154-70-8 | GNE-617 is a novel, potent and specific inhibitor NAMPT (nicotinamide phosphoribosyltransferase) that inhibits the biochemical activity of NAMPT with an IC50of 5 nM and exhibits efficacy in xenograft models of cancer. |
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V2814 | GNE-617 hydrochloride | 2070014-99-0 | GNE-617 hydrochloride is a specific inhibitor NAMPT (nicotinamide phosphoribosyltransferase) that inhibits the biochemical activity of NAMPT with an IC50of 5 nM and exhibits efficacy in xenograft models of cancer. |
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V84843 | HDAC/NAMPT-IN-1 | 2898381-63-8 | |
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V83679 | JGB-1-155 | 3011930-28-9 | |
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V51686 | LB-60-OF61 hydrochloride | 742064-38-6 | LB-60-OF61 HCl is a potent NAMPT inhibitor and LB-60-OF61 HCl is a cytotoxic compound selective for MYC-overexpressing cell lines. |
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V87636 | MS7 | 1593654-46-6 | MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). |
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V51682 | Nampt activator-1 | 701929-65-9 | Nampt activator-1 (compound 1) is a potent activator of nicotinamide phosphotransferase (NAMPT) with EC50 of 3.3-3.7 μM. |
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V51683 | Nampt activator-2 | 2237268-90-3 | Nampt activator-2 (compound 34) is a potent NAMPT activator with EC50 of 0.023 μM. |
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V51680 | Nampt activator-3 | 2790481-63-7 | NAMPT activator-3 is a NAT mimetic and a NAMPT activator with EC50 of 2.6 μM and a KD of 132 nM. |
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V85400 | Nampt activator-4 | 2847156-05-0 | |
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V83394 | Nampt activator-5 | ||
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V87635 | NAMPT activator-6 | 2237267-86-4 | NAMPT activator-6 is a NAMPT activator, a regulatory molecule for the optical control system of NAMPT and NAD+. |
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V87633 | NAMPT activator-7 | NAMPT activator-7 (Compound 232) is an activator of nicotinamide phosphotransferase (NAMPT) with EC50 <0.5 μM. | |
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V87634 | NAMPT activator-8 | NAMPT activator-8 (Compound 278) is an activator of nicotinamide phosphotransferase (NAMPT) with EC50 <0.5 μM. | |
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V51681 | NAMPT degrader-3 | NAMPT degrader-3 (compound C5) is a NAMPT degrader that depends on VHL and proteasomal means. | |
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V80893 | Nampt-IN-10 trihydrochloride | Nampt-IN-10 tri HCl (compound 4) is an inhibitor (blocker/antagonist) of phosphoribosyltransferase (NAMPT). | |
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V94229 | Nampt-IN-13 | 2592504-89-5 | Nampt-IN-13 (Example 58m) is a NAMPT inhibitor that can be used to synthesize antibody-drug conjugates (ADCs). |
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