AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V56183 | Bempedoic acid-d5 (ETC-1002-d5; ESP-55016-d5) | 2408131-71-3 | Bempedoic acid-d5 is the deuterated form of Bempedoic acid. | |
V11178 | Buformin | 692-13-7 | Buformin (NSC-528218; 1-butylbiguanide) is an orally bioavailableAMPKactivator approved for use as anantidiabetic drug. | |
V16495 | Buformin hydrochloride | 1190-53-0 | Buformin hydrochloride(NSC-528218; NSC528218;1-butylbiguanide) is an orally availableAMPKactivator used as anantidiabetic drug belonging to the biguanide class. | |
V78668 | CB1R/AMPK modulator 1 | CB1R/AMPK modulator 1 (Compound 38-S) is an orally bioactive CB1R/AMPK modulator with a Ki of 0.81 nM and a CB1R IC50 of 3.9 nM. | ||
V50991 | Chamaejasmine | 69618-96-8 | Chamaejasmine is a biflavonoid that can be extracted from the root of Daphne wolfberry and has anti-tumor activity. | |
V52231 | COH-SR4 | 73439-19-7 | COH-SR4 is an AMPK activator. | |
V0251 | Dorsomorphin (BML275) | 866405-64-3 | Dorsomorphin(BML-275) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor with a Ki of 109 nM in cell-free assays, exhibiting little effects against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3. | |
V0246 | Dorsomorphin 2HCl (BML275) | 1219168-18-9 | Dorsomorphin 2HCl (formerly BML-275 dihydrochloride) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor thatinhibits AMPK with a Ki of 109 nM in cell-free assays, exhibiting little inhibition against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3. | |
V3967 | EX-229 | 1219739-36-2 | EX229 (EX-229; AMPK Activator 991), a benzimidazole analog, is a novel, potent and allosteric AMPK (AMP-activated protein kinase) activator with Kd values of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively. | |
V21592 | Ginkgolide C (BN-52022) | 15291-76-6 | Ginkgolide C (BN-52022) is a naturally occuring product isolated from Ginko and a GABA-A receptor, α-1 GlyR, and PAF receptor antagonist. | |
V0249 | GSK621 | 1346607-05-3 | GSK621 is a novel, potent and selective activator of AMP-activated protein kinase (AMPK) with potential antitumor activity. | |
V0250 | HTH-01-015 | 1613724-42-7 | HTH-01-015 is a novel, potent and selective inhibitor of NUAK1( (NUAK family SnF1-like kinase-1)which can serve as useful chemical probes to delineate the biological roles of the NUAK kinases. | |
V80316 | HTH-02-006 | HTH-02-006 is a NUAK2 inhibitor (IC50=126nM). | ||
V84330 | IND 1316 | 1888473-12-8 | ||
V51942 | IQZ23 | 2415643-79-5 | IQZ23 inhibits adipocyte differentiation by activating AMPK signaling pathway. | |
V55744 | Kazinol U | 1238116-48-7 | Kazinol U inhibits melanogenesis by inhibiting tyrosinase-related proteins through AMPK activation. | |
V40864 | Lixumistat (IM156) | 1422365-93-2 | IM156 (IM-156; IM 156;HL-156A;HL156A) is a metformin/biguanideanalogwith potential anticancer and neuroprotective activity. | |
V39112 | Lixumistat (IM156; HL156A; HL271) acetate | 1422365-94-3 | IM156 (also known as HL-156A; Lixumistat; HL-271) is a metforminderivative thac acts as a novel and highly potent AMPK activator that increases AMPK phosphorylation. | |
V13330 | Marein | 535-96-6 | Marein has neuro-protective (neuro-protection) effects by reducing damage to mitochondrial function and activation of the AMPK signaling pathway. | |
V55745 | MARK-IN-4 | 1990492-86-8 | MARK-IN-4 is a potent inhibitor of microtubule affinity-regulated kinase (MARK) with IC50 of 1 nM. |