AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V9698 | 6-Gingerol | 23513-14-6 | [6]-Gingerol is an active substance extracted from ginger that has a variety of bioactivities like anti-cancer, anti~inflammatory, and antioxidant. |
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V0244 | A-769662 | 844499-71-4 | A-769662 (A769662;A 769662), a thienopyridone analog, is a potent, alloesteric and reversible activator of AMPK (AMP-activated protein kinase)with antidiabetic activity. |
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V88833 | A17 | 2568186-47-8 | A17 is a bile acid analog with anti-nonalcoholic steatohepatitis (NASH) and anti-inflammatory activities. |
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V52430 | Aldometanib (LXY-05-029) | 2904601-67-6 | Aldometanib (LXY-05-029) is an aldolase inhibitor. |
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V97095 | ALKBH1-IN-3 | ALKBH1-IN-3 is a potent inhibitor of the DNA N6-methyladenosine (6mA) demethylase ALKBH1. | |
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V96679 | ALKBH1-IN-3 prodrug | ALKBH1-IN-4 prodrug (compound 29E) is a prodrug of the DNA N6-methyladenine demethylase ALKBH1 inhibitor, which can significantly increase the abundance of cellular 6mA, upregulate the AMPK signaling pathway, and inhibit the vitality of gastric cancer cells. | |
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V77269 | AMARA peptide TFA | AMARA peptide (TFA) is a substrate of salt-induced kinase (SIK) and adenylate-activated protein kinase (AMPK). | |
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V55721 | AMPK activator 10 | 1914176-03-6 | AMPK activator 10 is an orally bioactive AMPK activator with an EC150 of 44.3 nM as measured by cell ELISA. |
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V52421 | AMPK activator 11 | 2948304-00-3 | AMPK activator 11 is an AMP-activated protein kinase activator with nano-level anti-tumor activity and can resist a variety of CRC. |
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V55742 | AMPK activator 12 | 431920-24-0 | AMPK activator 12 (compound 21) is a potent AMPK activator and GDF15 inducer. |
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V77939 | AMPK activator 13 | AMPK activator 13 is a potent AMPK activator. | |
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V85432 | AMPK activator 14 | 1356632-18-2 | |
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V77267 | AMPK activator 2 hydrochloride | AMPK activator 2 (compound 7a) HCl is a fluoroguanil analogue that upregulates the AMPK signaling pathway and downregulates mTOR/4EBP1/p70S6K. | |
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V52420 | AMPKactivator 4 | 2493239-46-4 | AMPK activator 4 is a potent AMPK activator and does not inhibit mitochondrial complex I. |
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V55743 | AMPKactivator 9 | 1858204-23-5 | AMPK activator 9 (ZM-6) is a potent activator of AMPK (α2β1γ1) with EC50 of 1.1 µM. |
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V52419 | AMPK-IN-1 | 1219739-95-3 | AMPK-IN-1 is an AMPK activator (EC50 551 nM for isoform α2β2γ1). |
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V88838 | AMPK-IN-4 | 873077-70-4 | AMPK-IN-4 (compound 19) is a potent inhibitor of AMPK(α1) and AMPK(α2) with IC50 of 393 nM and 141 nM, respectively. |
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V70222 | AMPK-α1β1γ1 activator 1 | 1943510-86-8 | AMPK-α1β1γ1 activator 1 (M1) is the acylglucuronide metabolite of the Indole-3-cancer-based AMPK activator. |
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V2166 | ASP4132 tosylate | 1640294-30-9 | ASP4132 tosylate (ASP-4132) is an oral bioavailable AMPK activator (EC50 = 18 nM) with potential anticancer activity. |
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V88832 | Asteltoxin | 79663-49-3 | Asteltoxin is an extracellular vesicle (EV) inhibitor that inhibits mitochondrial ATP synthase and mTORC1 activation. |
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