DNA methylation, which is the addition of a methyl group to the carbon atom five (C5) of cytosine, is carried out by a family of "writer" enzymes called DNA methyltransferases (DNMTs). De novo methyltransferases (DNMT3A-DNMT3B), DNMT1, DNMT2, DNMT3C, and DNMTL are the five DNMTs that mammals encode. The three active enzymes that maintain DNA methylation are DNMT1, DNMT3A, and DNMT3B. While DNMT2 functions as a tRNA transferase rather than a DNA methyltransferase, DNMT3L lacks catalytic activity and regulates DNMT3A and DNMT3B.
By regulating gene expression without altering the DNA sequence, DNA methylation is a crucial modification process in the control of genetic information. For transcription, post-replicative mismatch repair, DNA replication control, cell cycle control, bacterial virulence, and the distinction between self and non-self DNA in prokaryotes, DNA methylation is crucial. DNA methylation is essential for many important physiological processes in mammals, including imprinting, the inactivation of the X chromosome, the silencing of germline-specific genes, and the silencing of repetitive elements.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79844 | DNMT2-IN-1 | DNMT2-IN-1 (compound 80) is a novel DNMT2 (DNA methyltransferase 2) inhibitor (antagonist) with IC50 of 1.2 μM for research into psychiatric and metabolic disorders or cancer diseases. | |
|
V88846 | DNMT3A-IN-3 | DNMT3A-IN-3 is an allosteric DNA methyltransferase 3A (DNMT3A) inhibitor. | |
|
V86244 | EcoGII Methyltransferase (EcoGII ) | ||
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V75485 | EcoRI Methyltransferase (EcoRI Methyltransferase) | 81458-00-6 | EcoRI Methyltransferase is a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase. |
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V79641 | GpC Methyltransferase (GpC ) | GpC Methyltransferase (GpC) is a DNA methylase. | |
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V37622 | GSK-3484862 | 2170136-65-7 | GSK-3484862 (GSK3484862) is a novel, potent and non-covalent Dnmt1(DNA methyltransferase) inhibitor with potential anticancer activity. |
|
V52034 | GSK3735967 | 2170136-86-2 | GSK3735967 is a selective, reversible, non-nucleoside DNMT1 inhibitor. |
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V75480 | HaeIII Methyltransferase (HaeIII) | 92228-40-5 | HaeIII Methyltransferase (HaeIII) is a methyltransferase that covalently binds to DNA. |
|
V75484 | Hhal Methyltransferase (Hhal ) | 91448-96-3 | Hhal Methyltransferase (Hhal) is a DNA methyltransferase (recognition sequence: GCGC). |
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V86140 | HpaII Methyltransferase (HpaII ) | 85537-81-1 | |
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V88849 | J208 | 2116468-11-0 | J208 is a dual inhibitor of histone deacetylase (HDAC) and DNA methyltransferase (DNMT). |
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V56178 | Levetiracetam-d3 (UCB L059-d3) | 1217851-16-5 | Levetiracetam-d3 is the deuterium labelled form of Levetiracetam. |
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V56177 | Levetiracetam-d6 (UCB L059-d6) | 1133229-29-4 | Levetiracetam-d6 is the deuterated form of Levetiracetam. |
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V85359 | METTL1-WDR4-IN-2 | 2919742-07-5 | |
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V88841 | METTL16-IN-1 | METTL16-IN-1 (Compound 45) is a potent METTL16 inhibitor with IC50 of 1.7 μM and Kd of 1.35 μM. | |
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V80846 | MspI Methyltransferase (MspI ) | MspI Methyltransferase (MspI) is a methyltransferase that recognizes the sequence CCGG and catalyzes the formation of 5-methylcytosine at the first C residue. | |
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V52884 | Procainamide (Procaine amide; SP 100) | 51-06-9 | Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). |
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V88847 | PROTAC METTL3-14 degrader 1 | PROTAC METTL3-14 degrader 1 (compound 30) is a PROTAC degrader of METTL3-14. | |
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V0405 | RG108 | 48208-26-0 | RG108, also known asN-Phthalyl-L-tryptophan,is a novel non-nucleoside inhibitor of DNA methyltransferase ((DNMT)with potential antitumor activity. |
|
V88328 | SARS-CoV-2-IN-87 | SARS-CoV-2-IN-87 (compound 138968421) is a potent inhibitor of methyltransferases (nsp14 and nsp16) of SARS-CoV-2. |
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