DNA methylation, which is the addition of a methyl group to the carbon atom five (C5) of cytosine, is carried out by a family of "writer" enzymes called DNA methyltransferases (DNMTs). De novo methyltransferases (DNMT3A-DNMT3B), DNMT1, DNMT2, DNMT3C, and DNMTL are the five DNMTs that mammals encode. The three active enzymes that maintain DNA methylation are DNMT1, DNMT3A, and DNMT3B. While DNMT2 functions as a tRNA transferase rather than a DNA methyltransferase, DNMT3L lacks catalytic activity and regulates DNMT3A and DNMT3B.
By regulating gene expression without altering the DNA sequence, DNA methylation is a crucial modification process in the control of genetic information. For transcription, post-replicative mismatch repair, DNA replication control, cell cycle control, bacterial virulence, and the distinction between self and non-self DNA in prokaryotes, DNA methylation is crucial. DNA methylation is essential for many important physiological processes in mammals, including imprinting, the inactivation of the X chromosome, the silencing of germline-specific genes, and the silencing of repetitive elements.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75480 | HaeIII Methyltransferase (HaeIII) | 92228-40-5 | HaeIII Methyltransferase (HaeIII) is a methyltransferase that covalently binds to DNA. |
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V75484 | Hhal Methyltransferase (Hhal ) | 91448-96-3 | Hhal Methyltransferase (Hhal) is a DNA methyltransferase (recognition sequence: GCGC). |
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V86140 | HpaII Methyltransferase (HpaII ) | 85537-81-1 | |
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V0335 | Levetiracetam (UCB-L 059, SIB-S 1) | 102767-28-2 | Levetiracetam (also known as UCB-L059, SIB-S1)is a potent and selective M2 muscarinic acetylcholine receptors (mAChR) inhibitor andan anticonvulsant medication used to treat epilepsy. |
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V56178 | Levetiracetam-d3 (UCB L059-d3) | 1217851-16-5 | Levetiracetam-d3 is the deuterium labelled form of Levetiracetam. |
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V56177 | Levetiracetam-d6 (UCB L059-d6) | 1133229-29-4 | Levetiracetam-d6 is the deuterated form of Levetiracetam. |
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V0409 | Lomeguatrib (PaTrin2) | 192441-08-0 | Lomeguatrib (formerly PaTrin-2) is a novel, potentand selective inhibitor of MGMT (O6-alkylguanine-DNA-alkyltransferase) with anticancer activity. |
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V85359 | METTL1-WDR4-IN-2 | 2919742-07-5 | |
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V80846 | MspI Methyltransferase (MspI ) | MspI Methyltransferase (MspI) is a methyltransferase that recognizes the sequence CCGG and catalyzes the formation of 5-methylcytosine at the first C residue. | |
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V52884 | Procainamide (Procaine amide; SP 100) | 51-06-9 | Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). |
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V0410 | Procainamide HCl | 614-39-1 | Procainamide HCl (known also as Procainamide hydrochloride; Procanbid; Procan) is an approved anti-arrhythmic drug that is used to treat cardiac arrhythmia by acting asa potent sodium channel blocker, and also a DNA methyltransferase inhibitor. |
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V0405 | RG108 | 48208-26-0 | RG108, also known asN-Phthalyl-L-tryptophan,is a novel non-nucleoside inhibitor of DNA methyltransferase ((DNMT)with potential antitumor activity. |
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V0408 | SGI-1027 | 1020149-73-8 | SGI-1027 is a novel and potent inhibitorof DNA methyltransferase (DNMT) with antineoplastic activity. |
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V0406 | Thioguanine (NSC-752; Tabloid) | 154-42-7 | Thioguanine (6-Thioguanine; NSC752; Tabloid; 2-Amino-6-purinethiol; 6-TG), an FDA approved medication used for treating AML-acute myeloid leukemia, is an antimetabolite anticancer drug, specifically, an anti-leukemia and immunosuppressant agent. |
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V0407 | Zebularine (NSC309132; 4-Deoxyuridine) | 3690-10-6 | Zebularine (formerly 4-Deoxyuridine; NSC-309132) is a selective and potent inhibitor of DNA methylation/methyltransferase with anticancer activity. |
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