ERK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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ERK

ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.The ERK pathway is activated by a wide range of stimuli, including as growth factors, cytokines, viral infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens. Ras stimulates c-Raf in the MAPK/ERK pathway, which is subsequently joined by mitogen-activated protein kinase kinase (also known as MKK, MEK, or MAP2K), followed by MAPK1/2 (see below).

Ras can be triggered by additional cues in addition to growth hormones through GRB2/SOS and receptor tyrosine kinases. Many transcription factors, including ELK1, and some downstream protein kinases are known to be activated by ERKs. Ras, c-Raf, and receptors like HER2 are known to cause disruption of the ERK pathway, which is frequently seen in malignancies.

ERK related products

Cat No.	Product Name	CAS No.	Product Description
V77039	Endothelin-1 (1-31) (Human) TFA		Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and blood pressure increase.
V69835	ERK-IN-2	2743576-56-7	ERK-IN-2 is an ERK2 inhibitor (antagonist) with IC50 of 1.8 nM.
V69836	ERK-IN-2 free base	2743576-55-6	ERK-IN-2 free base is an ERK2 inhibitor (antagonist) with IC50 of 1.8 nM.
V69834	ERK-IN-4	1049738-54-6	ERK-IN-4 is an ERK inhibitor that preferentially binds to ERK2 with a Kd of 5 μM.
V69832	ERK-IN-7	2494010-63-6	RK-IN-7 (Example 10) is an analog of SHR2415 and a potent ERK inhibitor (antagonist) with IC50s of 5 nM and 7 nM for ERK1 and ERK2, respectively.
V88086	ERK-IN-8	2226293-75-8	ERK-IN-8 (compound I-1) is an aniline pyrimidine derivative that acts as an ERK inhibitor.
V89609	ERK1/2 inhibitor 10		ERK1/2 inhibitor 10 (Compound 36c) is a potent inhibitor of ERK1 and ERK2 (IC50 of 0.11/0.08 nM, respectively).
V69806	ERK1/2 inhibitor 3	2737294-99-2	ERK1/2 inhibitor 3 is a potent ERK1/2 inhibitor.
V69820	ERK1/2 inhibitor 4	2490396-99-9	ERK1/2 inhibitor 5 is a potent ERK1/2 inhibitor.
V69810	ERK1/2 inhibitor 6	2634816-13-8	ERK1/2 inhibitor 6 is a potent ERK1/2 inhibitor.
V69826	ERK1/2 inhibitor 9	2169302-75-2	ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor.
V89775	ERK2 allosteric-IN-1	872591-16-7	ERK2 allosteric-IN-1 (compound 1) is a selective allosteric ERK2 inhibitor with IC50 of 11 μM.
V105113	ERK2 IN-5	353250-09-6	ERK2 IN-5 (compound 5g) is an inhibitor of ERK2 and exhibits good affinity for ERK2 and JNK3 with Ki of 86 and 550 nM, respectively.
V87069	ERK2-IN-4	933786-58-4	ERK2-IN-4 (Compound 6o) is a potent and selective ERK2 inhibitor with a Ki of 0.006 μM for ERK2.
V4799	ERK5-IN-2	1888305-96-1	ERK5-IN-2 is a novel, potent, orally bioavailable, sub-micromolar, and selective ERK5 inhibitor with selectivity over p38α and BRD4.
V69837	ERK5-IN-5	2318792-30-0	ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor (antagonist) with anti-cancer activity.
V69805	ERK5-IN-6	2734916-64-2	ERK5-IN-6 (compound 5J) is an ERK5 kinase inhibitor (antagonist) with anti-cancer activity.
V69815	ERKtide	287721-17-9	ERKtide is a biologically active peptide.
V102550	ETP-45835 dihydrochloride	2136571-30-5	D-106669 is an inhibitor of Erk2 with IC50 of 18.7 μM.
V0465	FR 180204	865362-74-9	FR-180204 (FR180204) is a novel, potent, selectiveand ATP-competitive inhibitor of ERK (extracellular signal-regulated kinase) with potential anti-inflammatory activity and has the potential to be used as a new therapy for rheumatoid arthritis.