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JNK

JNK

JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possesses a wide variety of regulatory functions.Three isoforms of the serine/threonine protein kinase JNK family (JNK1, JNK2, and JNK3) exist. JNKs play a role in the development and progression of many pathologies, including cancer, inflammatory diseases, cardiovascular and metabolic disorders, and neurodegenerative diseases.

JNKs are triggered by a phosphorylation cascade that typically involves two different upstream kinases, the so-called MAP kinase kinase kinases (MAP3K, MKKK) and the MAP kinase kinases (MAP2K; MKK). This process is similar to that used to activate the other MAP kinases. JNKs are triggered by MKK4 and MKK7 at the MAP2K level; the former is a shared activator of the JNK and p38 MAP kinase signaling pathways. The JNK cascade is a component of a complicated signaling network since it crosses numerous other routes at different places.

JNK related products

Structure Cat No. Product Name CAS No. Product Description
JNK-1-IN-4 V96640 JNK-1-IN-4 3047795-60-5 JNK-1-IN-4 (Compound E1) is a JNK inhibitor that inhibits JNK-1, JNK-2, and JNK-3 with IC50 of 2.7, 19.0, and 9.0 nM, respectively.
JNK-IN-12 V80459 JNK-IN-12 JNK-IN-12 (compound P2) is a mitochondria-targeted JNK inhibitor (IC50=66.3 nM), consisting of a mitochondria-specific cell-penetrable peptide and JNK-specific inhibitor SP600125.
JNK-IN-13 V74393 JNK-IN-13 345986-38-1 JNK-IN-13 (compound 1) is a potent and specific JNK inhibitor (antagonist) with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively.
JNK-IN-15, Cell-Permeable V85692 JNK-IN-15, Cell-Permeable
JNK-IN-15, Cell-Permeable, Negative Control V85683 JNK-IN-15, Cell-Permeable, Negative Control
JNK-IN-18 V94893 JNK-IN-18 JNK-IN-18 (compound 23b) is a JNK1 inhibitor with IC50 of 2 nM, while JNK2 and BRAF (V600E) have IC50s of 125 nM and 98 nM, respectively.
JNK-IN-19 V104592 JNK-IN-19 3059122-56-1 JNK-IN-19 (Compound Q8) is a c-Jun N-terminal kinase inhibitor used to treat and/or prevent pre-operative, intra-operative or post-operative injury.
JNK-IN-20 V104746 JNK-IN-20 346663-56-7 JNK-IN-20 (Compound 5) is a JNK inhibitor.
JNK-IN-21 V104754 JNK-IN-21 756849-36-2 JNK-IN-21 (Compound 62) is a JNK-1 inhibitor.
JNK-IN-22 V104735 JNK-IN-22 771503-50-5 JNK-IN-22 (Compound 58) is a JNK-1 inhibitor.
JNK-IN-7 V12253 JNK-IN-7 1408064-71-0 JNK-IN-7 is a potent JNK inhibitor, inhibiting JNK1, JNK2 and JNK3 with IC50 of 1.5, 2 and 0.7 nM respectively.
JNK2-IN-1 V78318 JNK2-IN-1 2998941-15-2 JNK2-IN-1 (Compound J27) is a JNK2 inhibitor (Kds: 79.2 Μm).
JNK3 inhibitor-3 V74392 JNK3 inhibitor-3 2873465-25-7 JNK3 inhibitor-3 (compound 15g) is a selective, BBB (blood-brain barrier) penetrating, orally bioactive c-Jun N-terminal kinase 3 (JNK3) inhibitor.
JNK3 inhibitor-6 V80457 JNK3 inhibitor-6 JNK3 inhibitor-6 (Compound A53) is a selective JNK3 inhibitor (IC50=78 nM).
JNK3 inhibitor-8 V80458 JNK3 inhibitor-8 JNK3 inhibitor-8 is a specific, orally bioactive JNK3 inhibitor that can cross the BBB (blood-brain barrier).
JNK抑制剂5a V0473 TCS JNK 5a 312917-14-9 TCS JNK 5a (alsoknown asJNK Inhibitor IX; TCS JNK-5a) is a novel, highly selective and potent JNK (c-Jun N-terminal Kinase) inhibitor with potential antineoplastic activity.
JNK抑制剂8 V0472 JNK-IN-8 1410880-22-6 JNK-IN-8 (JNK Inhibitor XVI; JNK-IN8) is the first irreversible/covalent inhibitor of pan-JNK (c-Jun N-terminal Kinase) with potential antitumor activity.
JNK抑制剂VIII V28892 JNK Inhibitor VIII (TCS JNK 6o) 894804-07-0 JNK Inhibitor VIII (TCS JNK 6o) isa selective and ATP-competitive inhibitor of c-Jun N-terminal kinases (JNK-1, -2, and -3) with Kis of 2 nM, 4 nM, 52 nM, respectively, and has IC50 of 45 nM and 160 nM for JNK-1 and -2, respectively.
KB-R7943 甲磺酸盐 V9844 KB-R7943 mesylate 182004-65-5 KB-R7943 mesylate, the mesylate salt of KB-R-7943, is a novel and potent reverse Na(+) /Ca(2+) exchanger (NCX(rev)) with neuroprotective action.
L-JNKI-1 V51552 L-JNKI-1 L-JNKI-1 is a cell-penetrable peptide inhibitor of JNK.
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