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MAP4K

MAP4K

MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of serine/threonine kinases.According to studies, MAP4Ks such as MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK, MAP4K4/HGK, MAP4K5/KHS, and MAP4K6/MINK cause JNK activation by triggering the MAP3K-MAP2K cascade. The regulation of cell migration, autophagy, apoptosis, and survival is greatly influenced by MAP4Ks. According to a number of studies, MAP4Ks control immune-cell responses through JNK-independent pathways.

When T-cells are activated and inflammatory responses are triggered, MAP4K1/HPK1 and MAP4K4/HGK play harmful roles. In contrast, MAP4K3/GLK contributes to the activation of T cells and autoimmune responses. Additionally, human autoimmune diseases like psoriatic arthritis, rheumatoid arthritis (RA), adult-onset Still's disease, and SLE involve MAP4K1 downregulation and MAP4K3 overexpression in T cells.

MAP4K related products

Structure Cat No. Product Name CAS No. Product Description
HPK1-IN-21 V74420 HPK1-IN-21 2413804-83-6 HPK1-IN-21 is a potent HPK1 kinase inhibitor (Ki=0.8 nM).
HPK1-IN-3 V74419 HPK1-IN-3 2739844-34-7 HPK1-IN-3 is a potent and specific ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor (antagonist) with IC50 of 0.25 nM.
HPK1-IN-31 V78360 HPK1-IN-31 3003026-16-9 HPK1-IN-31(compound 5i) is an orally bioactive hematopoietic progenitor kinase 1 (HPK1) inhibitor (antagonist) with IC50 of 0.8 nM.
HPK1-IN-32 V74418 HPK1-IN-32 2766481-17-6 HPK1-IN-32 is a potent and specific HPK1 inhibitor (antagonist) with IC50 of 65 nM.
HPK1-IN-33 V74423 HPK1-IN-33 2920000-86-6 HPK1-IN-33 (compound 21) is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 1.7 µM.
HPK1-IN-34 V74422 HPK1-IN-34 2380300-99-0 HPK1-IN-34 (Compound 143) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor (antagonist) with IC50 <100 nM.
HPK1-IN-35 V74421 HPK1-IN-35 2935903-77-6 HPK1-IN-35 is a potent and specific HPK1 inhibitor (antagonist) with IC50 of 3.5 nM.
HPK1-IN-36 V79825 HPK1-IN-36 2738518-06-2 HPK1-IN-36 (compound 2) is a potent HPK1 inhibitor (antagonist) with IC50 of 0.5 nM.
HPK1-IN-37 V74415 HPK1-IN-37 2766481-68-7 HPK1-IN-37 (compound A85)
HPK1-IN-38 V74414 HPK1-IN-38 2578802-72-7 HPK1-IN-38 (compound 15) is a MAP4K1/HPK1 inhibitor that may be utilized in the research/study of HPK1-related diseases.
HPK1-IN-39 V78722 HPK1-IN-39 HPK1-IN-39 (Compound 10n) is a selective HPK1 inhibitor (IC50= 29 nM).
HPK1-IN-4 V74400 HPK1-IN-4 2739844-28-9 HPK1-IN-4 (comp 22) is an inhibitor (blocker/antagonist) of HPK1 (MAPK41) (IC50 = 0.061 nM) and may be used in immunological research.
HPK1-IN-40-d2 V79108 HPK1-IN-40-d2 HPK1-IN-40 is a highly efficient and selective HPK1 inhibitor (antagonist) with IC50 of 0.9 nM.
HPK1-IN-41 V85285 HPK1-IN-41 2828455-23-6
HPK1-IN-42 V85125 HPK1-IN-42 2848684-50-2
HPK1-IN-43 V86874 HPK1-IN-43 HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with IC50 of 0.
HPK1-IN-44 V87079 HPK1-IN-44 HPK1-IN-44 (Compound 1) is an inhibitor of HPK1 (IC50 0.1 nM (40 μM ATP)).
HPK1-IN-45 V87081 HPK1-IN-45 HPK1-IN-45 (Compound 3) is a HPK1 inhibitor with IC50 of 0.3 nM.
HPK1-IN-47 V98261 HPK1-IN-47 2893885-42-0 HPK1-IN-47 is a PROTAC HPK1 degrader (DC50 in PBMCs: 23 nM).
HPK1-IN-48 V87084 HPK1-IN-48 HPK1-IN-48 (compound 14g) is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of 0.15 nM.
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