The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.
The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4240 | AZD7624 | 1095004-78-6 | AZD7624 is a novel, potent and selective inhaled p38 inhibitor with anti-inflammatory activity. |
|
V2686 | BMS-582949 | 623152-17-0 | BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM. |
|
V2668 | BMS-582949 HCl | 912806-16-7 | BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM. |
|
V74102 | BSJ-04-122 | 2513289-74-0 | BSJ-04-122 is a covalent MKK4/7 dual (bifunctional) inhibitor. |
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V74120 | Cannabisin D | 144506-19-4 | Cannabisin D inhibits glioblastoma cell growth/proliferation and migration through MAPK signaling. |
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V107611 | Carbimazole-d3 | Carbimazole-d3 is deuterated carbimazole. | |
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V102469 | CGH2466 dihydrochloride | 1177618-54-0 | CGH 2466 dihydrochloride is an orally active adenosine A1, A2B, and A3 receptor antagonist with IC50 values of 19 nM, 21 nM, and 80 nM, respectively. |
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V74106 | Cyclocurcumin | 153127-42-5 | Cyclocurcumin is a potent inhibitor of p38α. |
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V74105 | Darizmetinib | 2369583-33-3 | Darizmetinib is an inhibitor (blocker/antagonist) of mitogen-activated protein kinase kinase (MAP2K). |
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V69833 | DCZ19931 | 2789629-84-9 | DCZ19931 is a potent multi-targeted kinase inhibitor. |
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V74111 | Dehydromiltirone (1,2-Didehydromiltirone) | 116064-77-8 | Dehydromiltirone (1,2-Didehydromiltirone) is a diterpene quinone with anti-inflammatory activities. |
|
V74115 | Deoxysappanone B (3-Deoxysappanone B) | 113122-54-6 | Deoxysappanone B (3-Deoxysappanone B) is an isoflavone compound extracted from Caesalpinia sappan L (Lignum Sappan). |
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V94027 | Dilmapimod tosylate | 937169-00-1 | Dilmapimod mesylate is a potent p38 MAPK inhibitor that can effectively suppress inflammation caused by COPD. |
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V105331 | DK2403 | 2902651-64-1 | DK2403 (Compound 25) is a MAP2K7 inhibitor (IC50=0.01 μM). |
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V51072 | DL-Syringaresinol | 1177-14-6 | inhibitor of MAPK/AP-1 signaling |
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V74122 | EGF-R (661-681) T669 Peptide | 137348-21-1 | EGF-R (661-681) T669 Peptide is a MAPK substrate and may be utilized to measure MAPK catalytic activity. |
|
V74128 | Emprumapimod (PF-07265803) | 765914-60-1 | Emprumapimod (PF-07265803) is an orally bioactive, selective p38α MAPK inhibitor that directly inhibits LPS-induced IL-6 production in RPMI-8226 cells (IC50=100 pM). |
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V77040 | Emprumapimod hydrochloride (PF-07265803 hydrochloride) | Emprumapimod (PF-07265803) HCl is an orally bioactive and selective p38α MAPK inhibitor. | |
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V74108 | Esculin sesquihydrate (esculin sesquihydrate) | 66778-17-4 | Esculin sesquihydrate is a fluorescent coumarin glucoside, the active ingredient in ash bark. |
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V67591 | EW-7195 | 1352609-28-9 | EW-7195 is a potent and specific ALK5 (TGFβR1) inhibitor (antagonist) with IC50 of 4.83 nM. |
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