The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.
The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74119 | Ganoderterpene A | 2682180-85-2 | Ganoderterpene A alleviates LPS-induced inflammation and apoptosis by inhibiting MAPK and TLR-4/NF-κB pathways in BV-2 cells. |
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V103763 | GDC-3280 | 1590403-33-0 | GDC-3280 (AK3287; AKEX0011) is an orally active compound based on the pirfenidone phenylpyridone skeleton. |
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V96648 | Iroxanadine hydrobromide | 276690-62-1 | Iroxanadine hydrobromide (BRX 005) is a vasoprotective agent. |
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V94953 | Iroxanadine hydrochloride | 276690-59-6 | Iroxanadine hydrochloride (BRX 005) is a vasoprotective agent. |
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V73182 | Iroxanadine sulfate ((-)-BRX 005 sulfate; (-)-BRX 235 sulfate) | 276690-61-0 | Iroxanadine ((-)-BRX 005) sulfate is a potent activator of p38 kinase and an enhancer of stress-responsive heat shock protein (Hsp) expression. |
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V105278 | JD123 | 696629-98-8 | JD123 inhibits JNK1 activity and cJun (1-135) expression. |
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V74129 | JNJ-49095397 (RV568) | 1220626-82-3 | JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) that can inhibit the α and γ isoforms of p38 MAPK. |
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V105076 | KAI-11101 | KAI-11101 is an inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with Ki of 0.7 nM. | |
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V87097 | Klotho-derived peptide 1 | Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK) activation, and exhibits antifibrotic and renal protective effects in mouse models. | |
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V74114 | Macranthoin G (Methyl 3,5-dicaffeoyl quinic acid) | 159934-13-1 | Macranthoin G is an inhibitor (blocker/antagonist) of p38 MAPK. |
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V74104 | MBP MAPK Substrate | 138028-00-9 | MBP MAPK Substrate can be used as an exogenous substrate for MAPK. |
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V74116 | Mitogen-activated protein kinase 1 (MAPK1) | 137632-08-7 | Mitogen-activated protein kinase 1 (MAPK1) can activate the downstream p38/NF-κB pathway. |
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V69827 | MK2-IN-5 (Hsp25 kinase inhibitor; Mk2 pseudosubstrate) | 474713-20-7 | MK2-IN-5 is a pseudosubstrate of Mk2 (Ki= 8 μM). |
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V51569 | MKK7-COV-9 | 2283355-59-7 | covalent inhibitor of MKK7 |
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V87092 | Murrayafoline A | 4532-33-6 | Murrayafoline A is a carbazole alkaloid extracted from Murraya tetramera. |
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V74123 | Natsudaidain | 35154-55-3 | Natsudaidain is a polymethoxyflavonoid. |
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V87095 | NJK14047 | 1800576-41-3 | NJK14047 inhibits p38 MAPK and the differentiation of T cells into Th1 and Th17 cells. |
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V103650 | NR-11c | NR-11c is a selective and potent p38α PROTAC degrader. | |
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V51556 | OVA-E1 peptide | 153316-01-9 | antagonist variant of SIINFEKL [OVA (257-264) |
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V51557 | OVA-E1 peptide TFA | 1262750-80-0 | antagonist variant of SIINFEKL [OVA (257-264) |
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