The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.
The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V107298 | p-Cresol sulfate-d4 potassium | p-Cresol Sulfate-d4(Potassium) is deuterated p-Cresol Sulfate (Potassium). | |
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V74109 | p38 Kinase inhibitor 4 | 13142-47-7 | p38 Kinase inhibitor 4 (compound 135) is a potent p38 inhibitor. |
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V74118 | p38 Kinase inhibitor 5 | 2929285-29-8 | p38 Kinase inhibitor 5 (AA6) is a potent p38 kinase inhibitor (antagonist) with IC50 of 403.57 nM. |
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V74124 | p38 MAP Kinase Inhibitor VI | 421578-46-3 | p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor (antagonist) with an inhibition rate of 24%. |
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V51698 | p38 MAP modulator | 773104-07-7 | modulator of p38 Mitogen-Activated Protein (MAP) kinase |
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V74107 | p38 MAPK-IN-4 | 219138-24-6 | p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor, 50 at 35 nM. |
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V87098 | p38-α MAPK-IN-6 | 29368-40-9 | p38-α MAPK-IN-6 (compound 3a) is a p38α mitogen-activated protein kinase inhibitor. |
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V87096 | p38-α MAPK-IN-7 | p38-α MAPK-IN-7 (compound 4) is a p38α-MAPK inhibitor with IC50 of 98.7 nM. | |
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V74127 | p38α inhibitor 2 | 1095003-80-7 | p38α inhibitor 2 is a highly efficient and selective p38α MAPK inhibitor (antagonist) with pIC50 of 9.6. |
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V74126 | p38α inhibitor 4 | 1262406-08-5 | p38α inhibitor 4 (compound 10) is a selective allosteric p38α inhibitor (antagonist) with IC50 of 1.2 μM. |
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V103651 | p38α inhibitor 5 | 2550397-96-9 | p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand that targets p38 and can be used to synthesize NR-11c. |
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V104549 | p38α-MK2-IN-1 | 3031770-03-0 | p38α-MK2-IN-1 (Compound 36) is a p38α-MK2 complex inhibitor (IC50: 5 nM). |
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V3010 | PD 169316 | 152121-53-4 | PD 169316 is a novel potent, cell-permeable and specific/selective inhibitor of p38 MAPK kinase with IC50 value of 89 nM. |
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V84278 | Pestanoid A | ||
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V0481 | PH-797804 | 586379-66-0 | PH-797804 (PH797804), a diarylpyridinone analog,is a novel, potent, selective and ATP-competitive inhibitor of p38 mitogen-activated protein (p38α) with potential anti-inflammatory and anticancer activity. |
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V74121 | PLK1/p38γ-IN-1 | 2418614-81-8 | PLK1/p38γ-IN-1 (compound 14) is a multi-target inhibitor of PLK1 and p38γ. |
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V93145 | PS-166276 | 348089-57-6 | PS-166276 is a potent and low cytotoxic p38 inhibitor. |
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V4141 | R1487 HCl | 449808-64-4 | R1487 HCl is a novel, potent, orally bioavailable, and highly selective inhibitor of p38α mitogen-activated protein kinase. |
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V87091 | SB 203580 sulfone | 152121-46-5 | SB 203580 sulfone is an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes with an IC50 of 0.2 μM, and competitively binds to CSAID binding protein (CSBP), inhibiting CSBP activity and suppressing its-mediated stress response signaling with an IC50 of 0.03 μM. |
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V74110 | SB 706504 | 911110-38-8 | SB 706504 is a potent p38 MAPK inhibitor that can suppress Lipopolysaccharides-stimulated macrophage inflammatory gene expression in chronic obstructive pulmonary disease (COPD). |