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p38 MAPK

p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.

The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.

p38 MAPK related products

Structure Cat No. Product Name CAS No. Product Description
p-Cresol sulfate-d4 potassium V107298 p-Cresol sulfate-d4 potassium p-Cresol Sulfate-d4(Potassium) is deuterated p-Cresol Sulfate (Potassium).
p38 Kinase inhibitor 4 V74109 p38 Kinase inhibitor 4 13142-47-7 p38 Kinase inhibitor 4 (compound 135) is a potent p38 inhibitor.
p38 Kinase inhibitor 5 V74118 p38 Kinase inhibitor 5 2929285-29-8 p38 Kinase inhibitor 5 (AA6) is a potent p38 kinase inhibitor (antagonist) with IC50 of 403.57 nM.
p38 MAP Kinase Inhibitor VI V74124 p38 MAP Kinase Inhibitor VI 421578-46-3 p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor (antagonist) with an inhibition rate of 24%.
p38 MAP modulator V51698 p38 MAP modulator 773104-07-7 modulator of p38 Mitogen-Activated Protein (MAP) kinase
p38 MAPK-IN-4 V74107 p38 MAPK-IN-4 219138-24-6 p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor, 50 at 35 nM.
p38-α MAPK-IN-6 V87098 p38-α MAPK-IN-6 29368-40-9 p38-α MAPK-IN-6 (compound 3a) is a p38α mitogen-activated protein kinase inhibitor.
p38-α MAPK-IN-7 V87096 p38-α MAPK-IN-7 p38-α MAPK-IN-7 (compound 4) is a p38α-MAPK inhibitor with IC50 of 98.7 nM.
p38α inhibitor 2 V74127 p38α inhibitor 2 1095003-80-7 p38α inhibitor 2 is a highly efficient and selective p38α MAPK inhibitor (antagonist) with pIC50 of 9.6.
p38α inhibitor 4 V74126 p38α inhibitor 4 1262406-08-5 p38α inhibitor 4 (compound 10) is a selective allosteric p38α inhibitor (antagonist) with IC50 of 1.2 μM.
p38α inhibitor 5 V103651 p38α inhibitor 5 2550397-96-9 p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand that targets p38 and can be used to synthesize NR-11c.
p38α-MK2-IN-1 V104549 p38α-MK2-IN-1 3031770-03-0 p38α-MK2-IN-1 (Compound 36) is a p38α-MK2 complex inhibitor (IC50: 5 nM).
PD 169316 V3010 PD 169316 152121-53-4 PD 169316 is a novel potent, cell-permeable and specific/selective inhibitor of p38 MAPK kinase with IC50 value of 89 nM.
Pestanoid A V84278 Pestanoid A
PH-797804 V0481 PH-797804 586379-66-0 PH-797804 (PH797804), a diarylpyridinone analog,is a novel, potent, selective and ATP-competitive inhibitor of p38 mitogen-activated protein (p38α) with potential anti-inflammatory and anticancer activity.
PLK1/p38γ-IN-1 V74121 PLK1/p38γ-IN-1 2418614-81-8 PLK1/p38γ-IN-1 (compound 14) is a multi-target inhibitor of PLK1 and p38γ.
PS-166276 V93145 PS-166276 348089-57-6 PS-166276 is a potent and low cytotoxic p38 inhibitor.
R1487 HCl V4141 R1487 HCl 449808-64-4 R1487 HCl is a novel, potent, orally bioavailable, and highly selective inhibitor of p38α mitogen-activated protein kinase.
SB 203580 sulfone V87091 SB 203580 sulfone 152121-46-5 SB 203580 sulfone is an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes with an IC50 of 0.2 μM, and competitively binds to CSAID binding protein (CSBP), inhibiting CSBP activity and suppressing its-mediated stress response signaling with an IC50 of 0.03 μM.
SB 706504 V74110 SB 706504 911110-38-8 SB 706504 is a potent p38 MAPK inhibitor that can suppress Lipopolysaccharides-stimulated macrophage inflammatory gene expression in chronic obstructive pulmonary disease (COPD).
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