The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.
The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74125 | TLR4/NF-κB/MAPK-IN-1 | 2767567-26-8 | TLR4/NF-κB/MAPK-IN-1 is a new anti-neuroinflammatory agent by inhibiting the TLR4/NF-κB/MAPK pathway. |
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V74113 | Torilin | 13018-10-5 | Torilin is a sesquiterpene with antibacterial, anticancer and anti-inflammatory activities. |
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V0480 | VX-702 | 745833-23-2 | VX-702 is a novel, highly potent,orally bioavailableand selective inhibitor of p38α MAPK with potential anti-inflammatory activity. |
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