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p38 MAPK

p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.

The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.

p38 MAPK related products

Structure Cat No. Product Name CAS No. Product Description
(aS)-PH-797804 V84584 (aS)-PH-797804 1358027-80-1
(E)-紫萁酮 V51555 (E)-Osmundacetone 123694-03-1 neuroprotective agent
(R)-Afatinib ((R)-BIBW 2992) V69324 (R)-Afatinib ((R)-BIBW 2992) 439081-17-1 (R)-Afatinib ((R)-BIBW 2992) is an isomer of Afatinib.
(Z)-Tetradec-7-en-1-ol V90996 (Z)-Tetradec-7-en-1-ol 40642-43-1 (Z)-Tetradec-7-en-1-ol activator of mitogen-activated protein kinase (MAP Kinase).
(±)-Iroxanadine V102424 (±)-Iroxanadine 203805-20-3 (±)-Iroxanadine (BRX 005; BRX 235) is a vasoprotective agent and activator of p38 kinase and HSP proteins.
10-Methoxy-canthin-6-one V96882 10-Methoxy-canthin-6-one 86293-40-5 10-Methoxy-keratin-6-one (Mtx-C) is a DNA damage inducer.
1H-吲哚-5-甲酰胺 V14562 SD169 1670-87-7 SD-169 is an orally bioactive ATP-competitive MAPK p38α inhibitor (antagonist) with IC50 of 3.2 nM.
2-Oleoxyphenethyl phosphocholin V84202 2-Oleoxyphenethyl phosphocholin 2170888-41-0
2-Stearoxyphenethyl phosphocholin V84198 2-Stearoxyphenethyl phosphocholin 2170888-39-6
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine V67534 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine 2226941-29-1 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is a protein kinase inhibitor (antagonist) with IC50 of PKC-α, ROCK, and ASK1.
Acumapimod (BCT-197) V2863 Acumapimod (BCT-197) 836683-15-9 Acumapimod (also known as BCT197) is a potent and orally bioavailable small molecule inhibitor of the p38 MAP kinase (MAPK-mitogen-activated protein kinase) with an IC50 of less than 1 μM for p38α.
Anti-inflammatory agent 33 V74117 Anti-inflammatory agent 33 2816993-09-4 Anti-inflammatory agent 33 is a potent inhibitor of p38α.
Anti-osteoporosis agent-11 V96746 Anti-osteoporosis agent-11 2869099-50-1 Osteoporosis inhibitor-11 (compound 3k) is an osteoclast-targeting anti-osteoporosis compound.
Anti-osteoporosis agent-8 V87093 Anti-osteoporosis agent-8 Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor that inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation with IC50 of 2.41 μM.
ARRY614 V0484 Pexmetinib (ARRY-614) 945614-12-0 Pexmetinib (formerly ARRY614; ARRY-614) is a novel, potent, orally bioavailable, and dualinhibitor of p38 mitogen-activated protein kinase and Tie2 kinaseswith potential anti-inflammatory, anti-cancer andantiangiogenic activity.
ASK1-IN-1 V74103 ASK1-IN-1 2411382-24-4 ASK1-IN-1 is a CNS-penetrant apoptosis signal-regulated kinase 1 (ASK1) inhibitor (antagonist) with good potency (cellular IC50=138 nM; Biochemical IC50=21 nM).
Atraric acid (Methyl atrarate) V67600 Atraric acid (Methyl atrarate) 4707-47-5 Atraric acid (Methyl atrarate) is a specific androgen receptor antagonist (inhibitor) with anti-inflammatory and anti-cancer effects.
AZD7624 V4240 AZD7624 1095004-78-6 AZD7624 is a novel, potent and selective inhaled p38 inhibitor with anti-inflammatory activity.
BMS-582949 V2686 BMS-582949 623152-17-0 BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM.
BMS-582949 HCl V2668 BMS-582949 HCl 912806-16-7 BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM.
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