ATM ATR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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ATM ATR

It is well known that ATM/ATR, which belong to the phosphatidyl inositol 3-kinase-like family of serine/threonine protein kinases (PIKKs), are key players in the mitotic DNA damage response (DDR), which mounts responses to single-stranded DNA (ssDNA) and DNA double-strand breaks (DSBs), respectively. Ionizing radiation activates the signal transduction pathways that cause cell cycle arrest at G1/S, S, and G2/M by activating the ATM.In response to DNA-damaging agents like ultraviolet radiation that cause hefty lesions, ATR is necessary for cell cycle arrest.

In order to stabilize stalled replication forks, repair damaged DNA, and stop the cell cycle from continuing, ATM/ATR phosphorylate a wide range of targets upon activation. This helps to ensure cell survival and protect the integrity of the genome. The cell cycle checkpoints activated by ATM and ATR act as an active defense against tumorigenesis and genome instability in replicating cells.

ATM ATR related products

Cat No.	Product Name	CAS No.	Product Description
V77042	Elimusertib-d3 (BAY 1895344-d3)		Elimusertib-d3 (BAY 1895344-d3) is the deuterated form of Elimusertib-d3 (BAY 1895344-d3).
V3221	HAMNO (NSC111847)	138736-73-9	HAMNO (formerly known as NSC-111847) is a novel,potent and selective protein interaction inhibitor ofreplication protein A(RPA).
V88585	ICT10336		ICT10336 is a hypoxia-responsive prodrug of the ATR inhibitor AZD6738.
V70225	KU-60019	925701-46-8	KU-60019 is a specific inhibitor of ATM kinase with IC50 of 6.3 nM.
V70224	Mirin	299953-00-7	Mirin is a potent inhibitor of the Mre11-Rad50-Nbs1 (MRN) complex.
V88583	XRD-0394	2595308-10-2	XRD-0394 is an orally active, potent and specific dual inhibitor of ATM and DNA-PKcs.
V2965	Elimusertib (BAY1895344)	1876467-74-1	Elimusertib (formerly known as BAY-1895344) is a highly selective and orally bioavailable inhibitor of ATR(ataxia telangiectasia and Rad3-related) with potential anticancer activity.