PI3K

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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PI3K

PI3K (Phosphoinositide 3-kinase), via phosphorylation of the inositol lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), forms the second messenger molecule phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) which recruits and activates pleckstrin homology domain containing proteins, leading to downstream signalling events crucial for proliferation, survival and migration. The four distinct catalytic isoforms of class I PI3K enzymes are PI3K, PI3K, PI3K, and PI3K.
Three main classes of PI3K enzymes exist, with class IA being strongly linked to cancer. Catalytic subunits (p110α, p110β, or p110δ; encoded by PIK3CA, PIK3CB, and PIK3CD genes, respectively) and regulatory subunits (p85) make up heterodimeric lipid kinases known as class IA PI3K.

The PI3K pathway is crucial for the progression of the cell cycle, cell growth and survival, actin rearrangement and migration, and intracellular vesicular transport, among many other biological processes.

PI3K related products

Cat No.	Product Name	CAS No.	Product Description
V2910	ETP-46321	1252594-99-2	ETP-46321 is a novel, potent and orally bioavailable inhibitor of PI3Kα and PI3Kδ with Kiappvalues of 2.3 nM and 14.2 nM, respectively inbiochemical assays.
V69223	ETP-47037	1316760-76-5	ETP-47037 is a potent inhibitor of PI3Kα isoforms with IC50 of 0.99 nM.
V69233	FAP-PI3KI1	2415941-98-7	FAP-PI3KI1 is a fibroblast activation protein (FAP)-targeted PI3K inhibitor that can selectively target human idiopathic pulmonary fibrosis (IPF) cells expressing FAP and effectively inhibit collagen synthesis and reduce collagen deposition.
V69226	FD2056	2685870-87-3	FD2056 is a potent orally bioactive PI3K inhibitor.
V69197	FD274	2641899-38-7	FD274 is a potent dual (bifunctional) inhibitor of PI3K/mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM and 2.03 nM for PI3Kα/β/γ/δ and mTOR respectively.
V69202	Gallein (alizarin violet; Pyrogallol phthalein)	2103-64-2	Gallein is an inhibitor (blocker/antagonist) of G protein βγ (Gβγ) subunit signaling.
V4526	GDC-0326	1282514-88-8	GDC-0326 is a novel, potent and selectivePI3Kα (α-Isoform of Phosphoinositide 3-Kinase)inhibitor with aKiof 0.2 nM.
V70264	Gilmelisib	1845777-61-8	This product is discontinued due to commercial reason. Gilmelisib is an antitumor active molecule.
V0146	GNE-317	1394076-92-6	GNE-317, an oxetane analog of GDC-0980, is a novel, potent, and selective PI3K/mTOR dual inhibitor with excellent BBB (blood-brain barrier) penetrating ability.
V4333	GNE-477	1032754-81-6	GNE-477 is a novel, potent and efficacious dual inhibitor ofPI3K(IC50=4 nM)/mTOR(Ki=21 nM).
V0126	GSK1059615	958852-01-2	GSK1059615 is a novel, potent and reversible inhibitor of P13K (phosphatidylinositol-3-kinases) with potential anticancer activity.
V2546	GSK2292767	1254036-66-2	GSK2292767 is a novel and selective PI3Kδ inhibitor being investigator for the treatment of respiratory diseases such as asthma and COPD.
V0135	GSK2636771	1372540-25-4	GSK2636771 is a novel, potent, selective and orally bioavailable inhibitor of PI3Kβ (phosphatidylinositol 3-kinase β)with potential anticancer activity.
V0148	HS-173	1276110-06-5	HS-173 is a novel and potent PI3Kα (phosphatidylinositol 3-kinase) inhibitor (IC50 = 0.8 nM) with a potential to be used asan effective therapeutic agent for ameliorating liver fibrosis.
V103314	Hydroxy celecoxib	170571-00-3	Hydroxycelecoxib, a derivative of celecoxib, is a PI3K/Akt signaling pathway activator that promotes epithelial repair.
V0110	IC-87114	371242-69-2	IC-87114 is a novel, potent, selective andATP-competitive PI3Kδ inhibitor (p110delta-selective) with potential anticancer activity.
V97283	IHMT-PI3K-315		IHMT-PI3K-315 (20e) is a potent and selective PI3Kγ/δ inhibitor with IC50 values of 4.0 and 9.1 nM for PI3Kγ and PI3Kδ, respectively.
V80354	IHMT-PI3K-455		IHMT-PI3K-455 (Compound 15u) is a specific and orally bioactive dual PI3Kγ/δ inhibitor.
V76896	iMDK quarterhydrate		iMDK quarterhydrate is a potent PI3K inhibitor that suppresses the growth factor MDK (also known as midkine or MK).
V3109	IPI-3063	1425043-73-7	IPI-3063 is a potent and selective PI3Kp110δinhibitor with IC50 of 2.5 ± 1.2 nM and IC50 values of >1000 nM for other classes of PI3K isoforms (p110α, p110β, p110γ).