E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82481	Thalidomide-NH-(CH2)2-NH-Boc	1957235-57-2	Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide that can serve as a Cereblon ligand to recruit CRBN proteins.
V81570	Thalidomide-NH-amido-C2-NH2 hydrochloride		Thalidomide-NH-amido-C2-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79993	Thalidomide-NH-amido-C3-NH2 hydrochloride		Thalidomide-NH-amido-C3-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79919	Thalidomide-NH-amido-C4-NH2 hydrochloride		Thalidomide-NH-amido-C4-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82475	Thalidomide-NH-amido-C5-NH2	2763827-12-7	Thalidomide-NH-amido-C5-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V81571	Thalidomide-NH-amido-C5-NH2 hydrochloride		Thalidomide-NH-amido-C5-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79565	Thalidomide-NH-amido-C6-NH2 hydrochloride		Thalidomide-NH-amido-C6-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79156	Thalidomide-NH-amido-C8-NH2		Thalidomide-NH-amido-C8-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V81572	Thalidomide-NH-amido-C8-NH2 hydrochloride		Thalidomide-NH-amido-C8-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79921	Thalidomide-NH-amido-PEG1-C2-NH2		Thalidomide-NH-amido-PEG1-C2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V81573	Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride		Thalidomide-NH-amido-PEG1-C2-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79647	Thalidomide-NH-amido-PEG2-C2-NH2		Thalidomide-NH-amido-PEG2-C2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V81574	Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride		Thalidomide-NH-amido-PEG2-C2-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79215	Thalidomide-NH-amido-PEG3-C2-NH2		Thalidomide-NH-amido-PEG3-C2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V79216	Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride		Thalidomide-NH-amido-PEG3-C2-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V81575	Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride		Thalidomide-NH-amido-PEG4-C2-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82383	Thalidomide-NH-C10-NH2 hydrochloride	2460022-53-9	Thalidomide-NH-C10-NH2 HCl is a cereblon ligand based on Thalidomide that recruits CRBN protein.
V82393	Thalidomide-NH-C9-NH2 hydrochloride	2305936-77-8	Thalidomide-NH-C9-NH2 HCl is a cereblon ligand based on Thalidomide that recruits CRBN protein.
V51307	Thalidomide-NH-PEG7	2641838-98-2	Thalidomide-NH-PEG7 is a ligand (for E3 ligase)-linker conjugate used in the preparation /synthesis of ADCs.
V51726	Thalidomide-NH-PEG8-Ts	2488761-07-3	Thalidomide-NH-PEG8-Ts is a ligand (for E3 ligase )-linker conjugate, which contains Thalidomide-based cereblon ligand and 8-unit PEG linker for PROTAC technology, like Can synthesize IDO1 PROTAC protein degrader.