E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82395	HG-7-85-01-Decyclopropane (PROTAC ABL binding moiety 3)	2444044-44-2	HG-7-85-01-Decyclopropane is a ligand based on HG-7-85-01 (ABL inhibitor), which can bind to IAP ligand through a linker to form a SNIPER molecule.
V101588	HL389-NHC2-PEG3-C2NH		HL389-NHC2-PEG3-C2NH can inhibit the proliferation of cancer cells MDA-MB-231 and MCF-7, with IC50 of 11.39μM and 9.66μM, respectively.
V82482	HO-PEG7-CH2COOH	2250056-27-8	HO-PEG7-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82441	HyNic-PEG2-DBCO	2741281-12-7	HyNic-PEG2-DBCO is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V82341	IMD-biphenylA	2928463-40-3	IMD-biphenylA is a novel imidazoquinolinone NF-κB Immune-modulatory dimer that can improve the adjuvant properties of small molecule immune enhancers.
V82358	IMD-vanillin	2928463-38-9	IMD-vanillin is a novel imidazoquinolinone NF-κB Immune-modulatory dimer.
V82359	IR-Crizotinib	2387927-74-2	IR-Crizotinib is an NF-κB inducing kinase (NIK) inhibitor that can cross the BBB (blood-brain barrier) and fluorescently localize glioblastoma (GBM) in the brain of mice (IC50= 3.381 μM).
V97118	JQ-1 (carboxylic acid)-NH-C2-NH-COOH		JQ-1 (carboxylic acid)-NH-C2-NH-COOH is an E3 ligase ligand-linker conjugate composed of JQ-1 carboxylic acid and the corresponding linker (2-aminoethyl)carbamate.
V96639	JQ-1 carboxylic acid-PEG3-C2-NH2	2098790-24-8	JQ-1 Carboxylic Acid-PEG3-C2-NH2 is an E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC.
V107938	JQ-1 carboxylic acid-PEG3-C2-NH2 HCL	2241669-80-5	JQ-1 carboxylic acid-PEG3-C2-NH2 HCL is an E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC.
V104650	L321-NH-C3-PEG3-C1-NH2		L321-NH-C3-PEG3-C1-NH2 (CRBN ligand L321) is a conjugate of the E3 ligase ligand and the BRD4 PROTAC L134 linker.
V84864	Lenalidomide 4'-PEG1-azide	2399455-45-7
V89505	Lenalidomide nonanedioic acid		Lenalidomide nonanedioic acid is a conjugate of the E3 ligase ligand and linker of LHF418.
V82517	Lenalidomide-4-aminomethyl	790652-68-5	Lenalidomide-4-aminomethyl is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82463	Lenalidomide-4-aminomethyl hydrochloride	444289-05-8	Lenalidomide-4-aminomethyl HCl is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V92062	Lenalidomide-5-bromopentanamide	2545963-24-2	Lenalidomide-5-bromopentanamide is the E3 ligase ligand-linker conjugate in PROTAC ATR degrader-2, composed of the CRBN ligand Lenalidomide and the linker 5-Bromopentanoyl chloride.
V94419	Lenalidomide-7-bromohept-1-yne	2619511-78-1	Lenalidomide-7-bromohept-1-yne is an E3 ligase ligand-linker conjugate that can be used to synthesize PRPTAC.
V101198	Lenalidomide-acetylene-C3-MsO	2138441-31-1	Lenalidomide-acetylene-C3-MsO is a conjugate of E3 ligase ligand and linker used to synthesize SIAIS039.
V97269	Lenalidomide-C3-PEG3-N3		Lenalidomide-C3-PEG3-N3 is an E3 ligase ligand-linker conjugate.
V102151	Lenalidomide-C6-Br	2580970-60-9	Lenalidomide-C6-Br is a ligand-linker conjugate for E3 ligase.