E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V78871	Thalidomide-O-C11-acid		Thalidomide-O-C11-acid is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V84944	Thalidomide-O-C3-azide	2758432-00-5
V82500	Thalidomide-O-C3-NH2	2509360-22-7	Thalidomide-O-C3-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V84778	Thalidomide-O-C5-azide	2411098-96-7
V82408	Thalidomide-O-C6-azide	2411389-65-4	Thalidomide-O-C6-azide is an E3 ligase (e.g. CRBN) ligand-linker conjugates containing a cereblon ligand based on Thalidomide (Thalidomide) and a linker.
V76422	Thalidomide-Piperazine-PEG1-NH2 diTFA		Thalidomide-Piperazine-PEG1-NH2 diTFA is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V76421	Thalidomide-Piperazine-PEG2-NH2 diTFA		Thalidomide-Piperazine-PEG2-NH2 diTFA is a ligand (for E3 ligase )-linker conjugate containing a Thalidomide-based cereblon ligand and 1 linker.
V82403	Thiol-C10-amide-PEG8	1353948-95-4	Thiol-C10-amide-PEG8 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82466	Thiol-C9-PEG5	130727-42-3	Thiol-C9-PEG5 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82515	Thiol-C9-PEG7	130727-44-5	Thiol-C9-PEG7 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82510	THP-CH3-ethyl propionate	3539-40-0	THP-CH3-ethyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V82458	THP-PEG1-THP	71033-27-7	THP-PEG1-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82438	Tos-PEG2-THP	69502-32-5	Tos-PEG2-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82426	Tos-PEG3-CH2COOtBu	1530778-24-5	Tos-PEG3-CH2COOtBu is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82404	Triethylene glycol monododecyl ether	3055-94-5	Triethylene glycol monododecyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the PEG (Polyethylene glycol) class and may be utilized to prepare PROTAC molecules.
V82445	Trt-PEG4-C2-acid hydrate	1189873-11-7	Trt-PEG4-C2-acid (hydrate) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V84214	VH 101 phenol-alkylC4-amine dihydrochloride	2564467-03-2
V84355	VH032 amide-PEG1-acid	2172820-07-2
V82506	VH032 analogue-1	2111829-84-4	VH032 analogue-1 is a VH032 analogue that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins.
V82372	VH032-C2-NH-Boc	2361119-87-9	VH032-C2-NH-Boc is a Boc-modified VH032 , which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein.