E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V97331	(S,R,S)-AHPC-p-toluic acid		(S,R,S)-AHPC-p-toluate is an E3 ubiquitinase ligand + adaptor conjugate.
V77947	(S,R,S)-AHPC-PEG1-OTs (VH032-PEG1-OTs; VHL Ligand-Linker Conjugates 2; E3 ligase Ligand-Linker Conjugates 51)		(S,R,S)-AHPC-PEG1-OTs is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC-based VHL ligand and 1 unit PEG linker .
V94641	(S,R,S)-AHPC-PEG2-C5-N3		(S,R,S)-AHPC-PEG2-C5-N3 is a synthetic E3 ligase ligand-linker conjugate.
V84609	(S,R,S)-AHPC-PEG3-NH2 dihydrochloride (VH032-PEG3-NH2 dihydrochloride; VHL Ligand-Linker Conjugates 1 dihydrochloride; E3 ligase Ligand-Linker Conjugates 5 dihydrochloride)	2376990-24-6
V97303	(S,R,S)-AHPC-phenylacetic acid	2010985-19-8	(S,R,S)-AHPC-phenylacetic acid is an E3 ligase ligand-adapter conjugate.
V84737	(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid)	2172819-72-4
V89494	(S,R,S)-Me-AHPC-amide-C3-alkyne		(S,R,S)-Me-AHPC-amide-C3-alkyne is a conjugate of E3 ligase ligand and linker, which is used to synthesize JWZ-5-13.
V92068	(S,S,R)-AHPC-C6-NH2	2411422-68-7	(S,S,R)-AHPC-C6-NH2 is the E3 Ligase Ligand-Linker Conjugate in the HL-8 structure.
V102260	(S,S,R)-AHPC-C6-NH2 hydrochloride		(S,S,R)-AHPC-C6-NH2 hydrochloride is the hydrochloride salt form of (S,S,R)-AHPC-C6-NH2.
V82360	(−)-N-Hydroxyapiosporamide (NHAP)	1205676-02-3	(−)-N-Hydroxyapiosporamide (NHAP) is an alkaloid and an NF-κB inhibitor (antagonist) with potent anticancer effect in vitro and in vivo.
V99870	1-Piperazinehexanoic acid-thalidomide	2819682-33-0	1-Piperazinehexanoic acid-thalidomide is a conjugate of E3 ligase ligand and linker and is a key intermediate in the synthesis of complete JMV7048.
V105015	2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl)acetate	1489237-17-3	2-(2-Aminoethoxy)ethyl 2-(adamantan-1-yl) acetate is a conjugate of a Hyt hydrophobic group and a linker and can be used to synthesize SARD279.
V89513	2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP		2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP is an E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC SOS1 degrader-10.
V93735	3-Hydroxyazetidine-Cyclohexanol-5-Aminothalidomide		3-Hydroxyazetidine-cyclohexanol is an E3 ubiquitin ligase ligand-linker conjugate that can be used to synthesize ALK PROTACs.
V99856	3-Hydroxypropanoic acid-pip-hydroquinone-dihydrouracil		3-Hydroxypropionic acid-pip-hydroquinone-dihydrouracil is a conjugate of E3 ligase ligand and linker and is a key intermediate for the synthesis of the complete PROTAC HPK1 degrader-2.
V99904	5-Aminothalidomide-cyclohexane	2924858-26-2	5-Aminothiazine-cyclohexane is an E3 ubiquitin ligase ligand-adapter conjugate.
V104440	6-Aminocaproic acid-(S,R,S)-AHPC-Me	2380273-49-2	6-Aminohexanoic acid-(S,R,S)-AHPC-Me is a PROTAC E3 ubiquitin ligase ligand and linker that can be used to synthesize PVD-06 and used in tumor research.
V97319	8-Hydroxyoctanoic acid-thalidomide	2399454-65-8	8-Hydroxyoctanoic acid-thalidomide is an E3 ligase ligand-adapter conjugate.
V82422	A 410099.1,amine-Boc	1613552-03-6	A 410099.1, amine-Boc is an IAP ligand that may be utilized in the synthesis/preparation of PROTACs, such as PROTACs against BTK (PROTACs 4 and 5).
V97421	Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo		Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo is an E3 ligase ligand-linker conjugate.