E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V82433 | Boc-PEG5-methyl ester | 1807530-04-6 | Boc-PEG5-methyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82448 | Boc-PEG8-Boc | 1432970-18-7 | Boc-PEG8-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
V82364 | Boc-Pip-alkyne-Ph-COOH | 2581824-70-4 | Boc-Pip-alkyne-Ph-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker (PROTAC (PROteolysis TArgeting Chimera) linker), belonging to the alkyl/ether class. | |
V82369 | Br-PEG4-THP | 1803547-60-5 | Br-PEG4-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82430 | BRD4 ligand-Linker Conjugate 1 | 2154358-89-9 | BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that may be utilized to prepare PROTAC. | |
V82502 | Bromo-PEG3-THP | 220568-33-2 | Bromo-PEG3-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82396 | BzNH-BS | 2443928-42-3 | BzNH-BS contains two different ligands, MeBS and benzoyl-amide. | |
V82512 | Cbz-PEG5-Br | 2710803-69-1 | Cbz-PEG5-Br is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. | |
V82484 | CC-3060 | 444288-86-2 | CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. | |
V82518 | Chloro-PEG2-Boc | 1442085-43-9 | Chloro-PEG2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82471 | CHO-CH2-PEG1-CH2-Boc | 2230956-95-1 | CHO-CH2-PEG1-CH2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
V78784 | cIAP1 Ligand-Linker Conjugates 10 (E3 ligase Ligand-Linker Conjugates 47) | cIAP1 Ligand-Linker Conjugates 10 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases. | ||
V77903 | cIAP1 Ligand-Linker Conjugates 13 (E3 ligase Ligand-Linker Conjugates 43) | cIAP1 Ligand-Linker Conjugates 13 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases. | ||
V82447 | cIAP1 Ligand-Linker Conjugates 16 | 2143956-63-0 | cIAP1 Ligand-Linker Conjugates 16 are E3 ligase ligand-linker conjugates for the synthesis of PROTACs. | |
V78785 | cIAP1 Ligand-Linker Conjugates 2 Hydrochloride (E3 ligase Ligand-Linker Conjugates 37 Hydrochloride) | cIAP1 Ligand-Linker Conjugates 2 HCl Contains cIAP ligand and linker for recruitment of E3 ubiquitin ligase. | ||
V78786 | cIAP1 Ligand-Linker Conjugates 4 (E3 ligase Ligand-Linker Conjugates 42) | cIAP1 Ligand-Linker Conjugates 4 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases. | ||
V78787 | cIAP1 Ligand-Linker Conjugates 6 hydrochloride (E3 ligase Ligand-Linker Conjugates 35 hydrochloride) | cIAP1 Ligand-Linker Conjugates 6 HCl Contains cIAP ligand and linker for recruitment of E3 ubiquitin ligase. | ||
V78788 | cIAP1 Ligand-Linker Conjugates 7 (E3 ligase Ligand-Linker Conjugates 44) | cIAP1 Ligand-Linker Conjugates 7 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases. | ||
V77904 | cIAP1 Ligand-Linker Conjugates 8 (E3 ligase Ligand-Linker Conjugates 46) | cIAP1 Ligand-Linker Conjugates 8 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases. | ||
V77921 | cIAP1 Ligand-Linker Conjugates 9 (E3 ligase Ligand-Linker Conjugates 45) | cIAP1 Ligand-Linker Conjugates 9 Contains cIAP ligands and linkers for recruiting E3 ubiquitin ligases. |