E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82418 | Cl-PEG4-acid | 158553-98-1 | Cl-PEG4-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V82343 | CP5V | 2509359-75-3 | CP5V is a PROTAC linked by von Hippel-Lindau ligand and CDK ligand, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination and proteasomal degradation. |
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V82474 | CRBNligand-9 | 55003-81-1 | CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). |
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V82416 | DBCO-NHCO-PEG2-maleimide | 2698339-31-8 | DBCO-NHCO-PEG2-maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V82480 | Decaethylene glycol dodecyl ether (PEG10-dodecyl) | 618113-48-7 | Decaethylene glycol dodecyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V82509 | Dimethylamino-PEG2-C2-NH2 | 692782-62-0 | Dimethylamino-PEG2-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82347 | DMAPT (Dimethylamino Parthenolide) | 791595-09-0 | DMAPT (Dimethylamino Parthenolide) is an analogue of Parthenolide (PTL) and an orally bioactive NF-κB inhibitor (antagonist) with an LD50 value of 1.7 μM against primary acute myeloid leukemia cells. |
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V82516 | Dodecylheptaglycol | 3055-97-8 | Dodecylheptaglycol is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |
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V82440 | DSPE-PEG2-mal | 1915739-87-5 | DSPE-PEG2-mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V82345 | dTAGV-1 TFA | 2624313-15-9 | dTAGV-1 TFA is a potent and specific degrader of mutant FKBP12F36V fusion protein. |
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V31357 | E3 ligase Ligand 17 hydrochloride | 2305369-00-8 | E3 ligase Ligand 17 hydrochloride is a ligand for E3 ubiquitin ligase. |
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V82494 | E3 ligase Ligand 18 | 2241669-88-3 | E3 ligase Ligand 18 is an E3 ubiquitin ligase ligand. |
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V31729 | E3 Ligase Ligand-Linker Conjugates 1 | 2097938-44-6 | E3 Ligase Ligand-Linker Conjugate 1 incorporates a ligand for the E3 ubiquitin ligase, and a PROTAC linker, which bring together target protein and ubiquitinating machinery. |
|
V31992 | E3 ligase Ligand-Linker Conjugates 14 | 1957236-21-3 | E3 ligase Ligand-Linker Conjugates 14 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
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V32227 | E3 ligase Ligand-Linker Conjugates 19 TFA | 1799711-25-3 | E3 ligase Ligand-Linker Conjugates 19 TFA is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
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V32177 | E3 Ligase Ligand-Linker Conjugates 2 | 1818885-63-0 | E3 Ligase Ligand-Linker Conjugates 2,(Pomalidomide-PEG4-Ph-NH2, Cereblon Ligand-Linker Conjugates 9)incorporates a ligand for the E3 ubiquitin ligase, and a PROTAC linker, which bring together target protein and ubiquitinating machinery. |
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V32005 | E3 Ligase Ligand-Linker Conjugates 20 TFA | 1950635-16-1 | E3 Ligase Ligand-Linker Conjugates 20 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
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V31913 | E3 Ligase Ligand-Linker Conjugates 52 (TFA) | 2022182-58-5 | E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) incorporates a CRBN ligand for the E3 ubiquitin ligase, and a PROTAC linker. |
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V82503 | E3 ubiquitin ligase binder-1 | 2446913-99-9 | E3 ubiquitin ligase binder-1 (compound 11) is a potent E3 ubiquitin ligase binder. |
|
V79294 | EN219-O-C4-NH2 TFA | EN219-O-C4-NH2 TFA contains ligands and linkers for recruiting E3 ubiquitin ligases. |
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