E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V84836	Pomalidomide 4'-alkylC3-azide	2357108-05-3
V84641	Pomalidomide 4'-alkylC4-acid	2225940-48-5
V51305	Pomalidomide 4'-PEG3-azide	2271036-46-3	Pomalidomide 4'-PEG3-azide is a synthetic ?E3 ligase ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which can be used for the synthesis of iRucaparib-TP3.
V84614	Pomalidomide 4'-PEG6-azide	2624181-62-8
V82432	Pomalidomide-5'-C8-acid	2682112-09-8	Pomalidomide-5'-C8-acid (Compound 3d') is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing Cereblon (CRBN) ligand based on Pomalidomide and 1 linker.
V82379	Pomalidomide-5-C10-NH2 hydrochloride	2863635-00-9	Pomalidomide-5-C10-NH2 HCl is a Pomalidomide based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82511	Pomalidomide-5-C5-NH2 hydrochloride	2925306-39-2	Pomalidomide-5-C5-NH2 HCl is a Pomalidomide based E3 ubiquitin ligase cereblon (CRBN) ligand that recruits cereblon proteins.
V82413	Pomalidomide-5-C8-NH2 hydrochloride	2863635-03-2	Pomalidomide-5-C8-NH2 HCl is a Pomalidomide based E3 ubiquitin ligase cereblon (CRBN) ligand that recruits cereblon proteins.
V82381	Pomalidomide-5-C9-NH2 hydrochloride	2925306-22-3	Pomalidomide-5-C9-NH2 HCl is a Pomalidomide based E3 ubiquitin ligase cereblon (CRBN) ligand that recruits cereblon proteins.
V82361	Pomalidomide-5-O-CH3	1547163-02-9	Pomalidomide-5-O-CH3 is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82457	Pomalidomide-6-OH	1547162-44-6	Pomalidomide-6-OH is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V81171	Pomalidomide-amido-C3-piperazine-N-Boc		Pomalidomide-amido-C3-piperazine-N-Boc is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing Pomalidomide-based cereblon ligand and linker, may be utilized to prepare PROTAC PD-1/PD-L1 degrader-1.
V82513	Pomalidomide-amino-PEG4-C4-Cl	2924835-36-7	Pomalidomide-amino-PEG4-C4-Cl (Intermediate 4d) is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing Pomalidomide based cereblon (CRBN) ligand and 1 linker.
V82371	Pomalidomide-amino-PEG5-NH2	2421217-04-9	Pomalidomide-amino-PEG5-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82378	Pomalidomide-C11-NH2 hydrochloride	2722611-55-2	Pomalidomide-C11-NH2 HCl is a Pomalidomide based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82456	Pomalidomide-C3-NH2	2093388-20-4	Pomalidomide-C3-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V86122	Pomalidomide-C5-azide	2434629-02-2
V82380	Pomalidomide-PEG5-C2-NH2 hydrochloride	2357117-23-6	Pomalidomide-PEG5-C2-NH2 HCl is a Pomalidomide based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82462	Propanol-PEG3-CH2OH	112935-57-6	Propanol-PEG3-CH2OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82467	Propargyl-PEG1-THP	119096-95-6	Propargyl-PEG1-THP is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.