E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82423	Propargyl-PEG2-urea-C3-triethoxysilane	1637329-79-3	Propargyl-PEG2-urea-C3-triethoxysilane is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82461	Propargyl-PEG3-PFP ester	2148295-91-2	Propargyl-PEG3-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82455	Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite	1682657-14-2	Propargyl-PEG5-1-ob-cyanoethyl-nn-diisopropylphosphoramidite is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82488	Propargyl-PEG5-Br	1287660-83-6	Propargyl-PEG5-Br is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82435	Propargyl-PEG6-Br	1973383-30-0	Propargyl-PEG6-Br is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82425	Propenyl-PEG3-Propenyl (Triethylene glycol diallyl ether)	90736-68-8	Propenyl-PEG3-Propenyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82460	PROTAC BRD4 ligand-2	2154358-11-7	PROTAC BRD4 ligand-2 is a ligand for the target protein BRD4 and may be used in the preparation /synthesis of PROTAC CFT-2718.
V82486	PROTAC Her3-binding moiety 1	1603845-36-8	PROTAC HER3-binding moiety 1 (compound 1b) is a ligand for Her3 protein.
V82464	PROTAC SMARCA2 degrader-1	2892523-73-6	PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM (SMARCA2) degrader (DC50<0.1 μM).
V82374	PROTAC SMARCA2 degrader-2	2892523-74-7	PROTAC SMARCA2 degrader-2 is a potent and specific SMARCA2/4 PROTAC degrader with IC50 of <0.1 μM in the HeLa HiBiT assay.
V82353	RO 106-9920	62645-28-7	Ro 106-9920 is a potent NF-kappaB inhibitor.
V82356	Rubioncolin C	132242-52-5	Rubioncolin C exerts anti-tumor activity in human cancer cells by inducing apoptosis and autophagic cell death and inhibiting the NF-κB and Akt/mTOR/P70S6K pathways.
V82350	Rubipodanone A	2170211-22-8	Rubipodanone A is a naphthohydroquinone dimer that is cytotoxic to A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells.
V82377	SCO-PEG3-NHS	2141976-25-0	SCO-PEG3-NHS is a PEG linker with a terminal imine (NH) group.
V82414	SMARCA-BD ligand 1 for Protac hydrochloride	2380272-56-8	SMARCA-BD ligand 1 HCl for Protac is a compound that can bind to the BAF ATPase subunit SMARCA2 and is based on PROTAC technology to degrade SMARCA2.
V82496	SPDP-PEG12-NHSester	2601437-72-1	SPDP-PEG12-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82349	Tazemetostat de(methyl morpholine)-COOH	2685873-44-1	Tazemetostat de(methyl morpholine)-COOH (compound 7) is a ligand for the PROTAC target protein EZH2 and may be utilized in the synthesis/preparation of EZH2 degraders (PROTACs).
V82436	TCO-PEG2-Sulfo-NHS ester	2353409-47-7	TCO-PEG2-Sulfo-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82386	TCO4-PEG2-Maleimide	2141981-85-1	TCO4-PEG2-Maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82389	TCO4-PEG3-Maleimide	1914971-04-2	TCO4-PEG3-Maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.