E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V97301	(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip		(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip is an E3 ligase ligand-adapter conjugate.
V97248	(R,S,R)-AHPC-PEG2-C2-boc		(R,S,R)-AHPC-PEG2-C2-boc is an E3 ubiquitinase ligand + linker conjugate.
V98703	(S)-Thalidomide-NH-cyclohexane-NH-Ph-NH2		(S)-thalidomide-NH-cyclohexane-NH-Ph-NH2 (compound C63) is a PROTAC E3 ligase + linker, which contains a thalidomide-based cereblon ligand and a linker and can be used to synthesize PROTACs.
V99665	(S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH		(S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH is a conjugate of the E3 ligase ligand and linker of PROTAC NCOA4 Degrader-1 (E3 ligase ligand-linker conjugate).
V97246	(S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin		(S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin is an E3 ubiquitinase ligand + adaptor conjugate.
V97270	(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin		(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin is an E3 ubiquitinase ligand + adaptor conjugate.
V82449	(S,R,S)-AHPC-C1-NH2 hydrochloride	2361120-26-3	(S,R,S)-AHPC-C1-NH2 HCl is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing a VHL complex based on (S,R,S)-AHPC. body and 1 linker, which may be utilized to prepare PROTAC molecules.
V82415	(S,R,S)-AHPC-C2-PEG3-BCN	2876198-36-4	(S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL ligand that may be utilized in the preparation /synthesis of PROTACs
V84667	(S,R,S)-AHPC-C3-COOH	2172819-73-5
V82406	(S,R,S)-AHPC-C3-NH2 dihydrochloride (VH032-C3-NH2 dihydrochloride)	2564467-25-8	(S,R,S)-AHPC-C3-NH2 (di-HCl) is the di-HCl salt form of (S,R,S)-AHPC-C3-NH2 .
V82491	(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2)	2170695-19-7	(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing the VHL ligand based on VH032 body and 1 linker.
V84649	(S,R,S)-AHPC-C5-NH2 dihydrochloride (VH032-C5-NH2 dihydrochloride)	2415256-20-9
V84528	(S,R,S)-AHPC-C7-amine dihydrochloride (VH032-C7-amine dihydrochloride)	2415256-17-4
V86270	(S,R,S)-AHPC-C7-amine hydrochloride (VH032-C7-amine hydrochloride)	2502189-41-3
V99920	(S,R,S)-AHPC-CO-bicyclo[2.2.2]octane-CHO		(S,R,S)-AHPC-O-Bicyclo-CO is an E3 ubiquitin ligase ligand-adaptor conjugate.
V97293	(S,R,S)-AHPC-CO-C-cyclohexane	2010985-17-6	(S,R,S)-AHPC-CO-C-cyclohexane is an E3 ubiquitinase ligand + adaptor conjugate.
V99960	(S,R,S)-AHPC-CO-C-Cyclohexene-Bpin		SMARCA2/4-ligand-adaptor-binding protein 4 is an E3 ubiquitin ligase ligand-adaptor binding protein.
V99940	(S,R,S)-AHPC-CO-C-piperazine	2940856-78-8	(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(piperazin-1-yl)acetylamino)butyryl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide is an E3 ubiquitin ligase ligand-adaptor complex.
V87922	(S,R,S)-AHPC-CO-C9-NH2	2349429-71-4	(S,R,S)-AHPC-CO-C9-NH2 is a Von Hippel-Lindau (VHL) amino building block that can be used to synthesize the E3 ligase ligands required for PROTACs.
V87919	(S,R,S)-AHPC-CO-C9-NH2 hydrochloride	2376139-50-1	(S,R,S)-AHPC-CO-C9-NH2 (hydrochloride) is a von Hippel-Lindau (VHL) amino building block that can be used to synthesize E3 ligase ligands required for PROTACs.