Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V82570	Acid-PEG25-NHSester	2563872-17-1	Acid-PEG25-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82573	Acid-PEG7-t-butyl ester	2134235-86-0	Acid-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82567	Amino-PEG16-acid	2922656-52-6	Amino-PEG16-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82599	Azido-PEG10-Boc	2490419-48-0	Azido-PEG10-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V82578	Azido-PEG12-alcohol	1111239-69-0	Azido-PEG12-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82538	Azido-PEG3-chloroacetamide	604766-23-6	Azido-PEG3-chloroacetamide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82550	Azido-PEG3-MS	176520-24-4	Azido-PEG3-MS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82581	Azido-PEG7-t-butyl ester	2596867-40-0	Azido-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82566	Azido-PEG9-S-methyl ethanethioate	2148986-33-6	Azido-PEG9-S-methyl ethanethioate is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82565	Benzyl-PEG24-alcohol	2218463-19-3	Benzyl-PEG24-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82592	Benzyl-PEG3-amine	86770-75-4	Benzyl-PEG3-amine is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82588	Benzyl-PEG6-MS	1262681-32-2	Benzyl-PEG6-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82553	Benzyl-PEG7-alcohol	423763-19-3	Benzyl-PEG7-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82530	Benzyl-PEG7-amine	868594-43-8	Benzyl-PEG7-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82569	Benzyl-PEG7-THP	230620-75-4	Benzyl-PEG7-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82594	Benzyloxy-C5-PEG1	159028-70-3	Benzyloxy-C5-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82552	Bis-PEG4-t-butyl ester	2100306-53-2	Bis-PEG4-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82597	Bis-PEG6-t-butyl ester	439114-12-2	Bis-PEG6-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82529	BOC-NH-PEG2-propene	2410236-85-8	BOC-NH-PEG2-propene is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82537	Br-PEG3-ethyl acetate	308085-31-6	Br-PEG3-ethyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.