A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V82596 | Br-PEG6-C2-NHBoc | 2688072-13-9 | Br-PEG6-C2-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V84420 | BWA-522 intermediate-1 | 2241315-66-0 | |
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V82546 | Chloroacetamido-PEG4-NHS ester | 1353011-95-6 | Chloroacetamido-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82563 | CHO-C-PEG2-C-CHO | 92351-72-9 | CHO-C-PEG2-C-CHO is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V84801 | cis VH-298 | 2097381-86-5 | |
|
V41476 | CRBN modulator 1 | 2407829-65-4 | CRBN modulator 1 is a thalidomide analog and a CRBN modulator(IC50 = 3.5 μM and Ki = 0.98 μM) disclosed inWO 2020006262. |
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V77102 | DCAF1 binder 1 | DCAF1 binder 1 is selective for the CRL4 DCAF1 E3 ligase complex. | |
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V3588 | E3 ligase Ligand 1 | 1948273-03-7 | E3 ligase Ligand 1 is a novel, potent and selective ligand for E3 Ligaseused inPROTACtechnology. |
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V82548 | E3 ligase Ligand 13 | 2701565-75-3 | E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand. |
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V3589 | E3 ligase Ligand 2 | 5054-59-1 | Thalidomide-4-OH (Cereblon ligand 2) is a Thalidomide-based Cereblon ligand that recruits CRBN protein. |
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V3590 | E3 Ligase Ligand 3 | 1061605-21-7 | E3 ligase Ligand 3, a carboxylic acid-functionalized analog of thalidomide, is a CRBN ligand for E3 Ligase used in PROTAC technology. |
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V3591 | E3 ligase Ligand 4 | 835616-60-9 | Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand that recruits CRBN protein. |
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V83797 | E3 Ligase Ligand-linker Conjugate 100 | ||
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V83771 | E3 Ligase Ligand-linker Conjugate 101 | ||
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V83773 | E3 Ligase Ligand-linker Conjugate 102 | ||
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V83778 | E3 Ligase Ligand-linker Conjugate 103 | ||
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V83733 | E3 Ligase Ligand-linker Conjugate 15 | 2716124-25-1 | |
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V83836 | E3 Ligase Ligand-linker Conjugate 27 | ||
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V83716 | E3 ligase Ligand-Linker Conjugate 31 | ||
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V83806 | E3 ligase Ligand-Linker Conjugate 32 |
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