A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V83823 | E3 ligase Ligand-Linker Conjugate 35 | ||
|
V83752 | E3 ligase Ligand-Linker Conjugate 40 | ||
|
V83799 | E3 ligase Ligand-Linker Conjugate 42 | ||
|
V83720 | E3 ligase Ligand-Linker Conjugate 46 | ||
|
V83792 | E3 Ligase Ligand-linker Conjugate 48 | 2520105-41-1 | |
|
V83758 | E3 Ligase Ligand-linker Conjugate 50 | 2918813-56-4 | |
|
V83744 | E3 Ligase Ligand-linker Conjugate 91 | 2229713-40-8 | |
|
V83780 | E3 Ligase Ligand-linker Conjugate 99 | ||
|
V82593 | Fmoc-NH-PEG3-amide-CH2OCH2COOH | 489427-26-1 | Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82598 | Fmoc-NH-PEG5-C2-NH2 | 2093277-71-3 | Fmoc-NH-PEG5-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82540 | Fmoc-Val-Phe-Boc | 258879-48-0 | Fmoc-Val-Phe-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and a maleimide-GGFG peptide linker. |
|
V82559 | Folate-MS432 | 2769735-56-8 | Folate-MS432 is a PROTAC that degrades MEKs in cancer/tumor cells in a folate receptor-dependent manner. |
|
V82541 | Hexaethylene glycol dimethyl ether | 1072-40-8 | Hexaethylene glycol dimethyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V82561 | HO-PEG5-CH2COOH | 52026-48-9 | HO-PEG5-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V79818 | HOXB7 8–25 (MDM2 32-46) | HOXB7 8–25 (MDM2 32–46) is an MDM2-derived peptide epitope that elicits antigen-specific and tumor-reactive CD4+ T cell responses. | |
|
V80546 | LCL-PEG3-N3 | LCL-PEG3-N3 is a decoy oligonucleotide E3 ligase ligand that may be utilized to develop chimeric molecules LCL-ER(dec) to degrade estrogen receptors. | |
|
V80547 | LCL-PEG3-N3 hydrochloride | LCL-PEG3-N3 ( HCl) is a decoy oligonucleotide E3 ligase ligand that may be utilized to develop chimeric molecules LCL-ER(dec) to degrade estrogen receptors. | |
|
V3396 | Lenalidomide (Revlimid, CC5013) | 191732-72-6 | Lenalidomide(Revlimid, CC-5013) is a derivative of thalidomide approved in the United States in 2005 for the treatment for myeloma and blood disorders called myelodysplastic syndromes. |
|
V84791 | Lenalidomide 4'-alkyl-C3-azide | 2399455-71-9 | |
|
V84868 | Lenalidomide 4'-alkyl-C5-azide | 2399455-78-6 |
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