Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V84798	Lenalidomide 4'-PEG1-amine dihydrochloride	2624336-86-1
V84823	Lenalidomide 4'-PEG2-amine dihydrochloride	2624336-88-3
V84544	Lenalidomide 4'-PEG2-azide	2399455-48-0
V84792	Lenalidomide 4'-PEG3-amine dihydrochloride	2624336-87-2
V83671	Lenalidomide 5'-piperazine	2222120-31-0
V83669	Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride	2520105-60-4
V33447	Lenalidomide hydrochloride	1243329-97-6	Lenalidomide HCl (formerly CC-5013; CC 5013; IMiD1; trade name Revlimid),the hydrochloride salt ofLenalidomide, is a derivative of thalidomide approved for use in the United States since 2005 in the treatment for myeloma and blood disorders called myelodysplastic syndromes.
V80239	Lenalidomide sodium (lenalidomide sodium; CC-5013 sodium)		Lenalidomide (sodium) is an analogue of Thalidomide and an orally bioactive immunomodulator that acts like a molecular glue.
V85047	Lenalidomide-C5-acid	2338824-30-7
V40200	Lenalidomide-OH	1416990-08-3	Lenalidomide-OH, a hydroxylated analog of Lenalidomide which is a cereblon (CRBN) ligand usedfor E3 ubiquitin ligase, can be used as a E3 ligase ligand in PROTACs for the recruitment of CRBN protein.
V82587	m-PEG3-S-PEG1-C2-Boc	2365419-97-0	m-PEG3-S-PEG1-C2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82571	m-PEG5-Propyne	1101668-41-0	m-PEG5-Propyne is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82536	Mal-amido-PEG24-acid	2171095-70-6	Mal-amido-PEG24-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82591	Mal-amido-PEG9-NHS ester	2575631-92-2	Mal-amido-PEG9-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82531	Mal-PEG2-NHS	329364-72-9	Mal-PEG2-NHS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V85910	MDM2-IN-23
V82532	Methyl-PEG3-bromide	72593-77-2	Methyl-PEG3-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82586	Methyltetrazine-PEG4-amine hydrochloride	2656478-51-0	Methyltetrazine-PEG4-amine ( HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82572	MS-PEG1-THP	1309248-13-2	MS-PEG1-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82584	MS-PEG3-dodecyl	2148295-99-0	MS-PEG3-dodecyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.