Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V83836	E3 Ligase Ligand-linker Conjugate 27
V83716	E3 ligase Ligand-Linker Conjugate 31
V83806	E3 ligase Ligand-Linker Conjugate 32
V83823	E3 ligase Ligand-Linker Conjugate 35
V83752	E3 ligase Ligand-Linker Conjugate 40
V83799	E3 ligase Ligand-Linker Conjugate 42
V83720	E3 ligase Ligand-Linker Conjugate 46
V83792	E3 Ligase Ligand-linker Conjugate 48	2520105-41-1
V83758	E3 Ligase Ligand-linker Conjugate 50	2918813-56-4
V83744	E3 Ligase Ligand-linker Conjugate 91	2229713-40-8
V83780	E3 Ligase Ligand-linker Conjugate 99
V3588	E3 ligase Ligand 1	1948273-03-7	E3 ligase Ligand 1 is a novel, potent and selective ligand for E3 Ligaseused inPROTACtechnology.
V82593	Fmoc-NH-PEG3-amide-CH2OCH2COOH	489427-26-1	Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82598	Fmoc-NH-PEG5-C2-NH2	2093277-71-3	Fmoc-NH-PEG5-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82540	Fmoc-Val-Phe-Boc	258879-48-0	Fmoc-Val-Phe-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and a maleimide-GGFG peptide linker.
V82559	Folate-MS432	2769735-56-8	Folate-MS432 is a PROTAC that degrades MEKs in cancer/tumor cells in a folate receptor-dependent manner.
V87932	GNE7599	2771069-76-0	GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a Kd of 540 pM.
V82541	Hexaethylene glycol dimethyl ether	1072-40-8	Hexaethylene glycol dimethyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V89050	HL389		HL389 can inhibit the proliferation of cancer cells MDA-MB-231 and MCF-7 with IC50 of 11.39 μM and 9.66 μM, respectively.
V82561	HO-PEG5-CH2COOH	52026-48-9	HO-PEG5-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.