Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V82533	MS-PEG4-THP	145927-73-7	MS-PEG4-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80904	N-Boc-SBP-0636457-OH		N-Boc-SBP-0636457-OH is a ligand for E3 ubiquitin ligase and is used for recruitment of IAP E3 ligase to degrade Bcl-xL.
V75863	NV03	2448341-58-8	NV03 is a potent and specific antagonist of the interaction between UHRF1 and H3K9me3 with a Kd of 2.4 μM.
V51743	OICR-8268		OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with Kd of 38 nM.
V84415	PD 4'-oxyacetic acid	2633633-12-0
V83784	Phenyl phenylcarbamate-CH-5-methoxypicolinamide-CH-CH-Ph-CF3
V84991	Phenyl-glutarimide 4'-oxyacetic acid	2782024-58-0
V83890	Phthalimidinoglutarimide-6-piperazine	2229723-92-4
V84535	Pomalidomide 4'-alkylC6-azide	2375555-72-7
V84689	Pomalidomide 4'-alkylC8-acid	2305936-70-1
V84537	Pomalidomide 4'-PEG5-azide	2624181-61-7
V84337	Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride	2758431-94-4
V85170	Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride	2758431-93-3
V76613	Pomalidomide-5-C11-NH2 hydrochloride		Pomalidomide-5-C11-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V76612	Pomalidomide-5-C12-NH2 hydrochloride		Pomalidomide-5-C12-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V78713	Pomalidomide-5-C13-NH2 hydrochloride		Pomalidomide-5-C13-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V78537	Pomalidomide-5-C14-NH2 hydrochloride		Pomalidomide-5-C14-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V80120	Pomalidomide-5-C3-NH2 hydrochloride		Pomalidomide-5-C3-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V81170	Pomalidomide-5-C4-NH2 hydrochloride		Pomalidomide-5-C4-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V80004	Pomalidomide-5-C6-NH2 hydrochloride		Pomalidomide-5-C6-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.