Ligands for E3 Ligase

+MORE

Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V79810	Pomalidomide-5-C7-NH2 hydrochloride		Pomalidomide-5-C7-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82580	Pomalidomide-amino-PEG4-NH2 hydrochloride	2331259-45-9	Pomalidomide-amino-PEG4-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82547	Pomalidomide-C11-NH2	2648285-39-4	Pomalidomide-C11-NH2 is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82595	Pomalidomide-C5-Dovitinib	2732969-67-2	Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib linked to CRBN.
V85999	Pomalidomide-C6-COOH	2225940-50-9
V86279	Pomalidomide-CO-C5-azide	2227423-33-6
V81172	Pomalidomide-PEG7-NH2 hydrochloride		Pomalidomide-PEG7-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82523	Propargyl-PEG5-PFP ester	2148295-92-3	Propargyl-PEG5-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82557	PROTAC BRD9 Degrader-2	2633631-78-2	PROTAC BRD9 Degrader-2 is a BRD9 bifunctional degrader for cancer research.
V82575	PROTAC BRD9 Degrader-3	2633632-05-8	PROTAC BRD9 Degrader-3 is a BRD9 bifunctional degrader for cancer research.
V82554	PROTAC CDK9 degrader-4	2411021-01-5	PROTAC CDK9 degrader-4 is a highly efficient, transcriptionally targeted CDK9 degrader.
V82528	PROTAC IRAK4 ligand-3	2434848-46-9	PROTAC IRAK4 ligand-3 is the ligand of PROTAC IRAK4 degrader-7 .
V82579	PROTAC TTK degrader-2	2953426-48-5	PROTAC TTK degrader-2 is a potent TTK (threonine tyrosine kinase) PROTAC degrader with DC50s of 3.1 and 12.4 nM in COLO-205 and HCT-116 cells, respectively.
V82568	S-acetyl-PEG4-amine	1404111-71-2	S-acetyl-PEG4-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82562	SCO-PEG4-COOH	2141976-27-2	SCO-PEG4-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category.
V82577	SCO-PEG8-COOH	2143968-79-8	SCO-PEG8-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category.
V84996	SJF-0661	2413035-43-3
V84437	SOS1 Ligand intermediate-1	2380273-21-0
V84448	SOS1 Ligand intermediate-2	2380273-24-3
V82582	t-Butyl acetate-PEG3-CH2COOH	1442466-57-0	t-Butyl acetate-PEG3-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.