A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V84545 | Thalidomide 4'-ether-PEG1-azide | 2758432-02-7 | ||
V82551 | Thalidomide-4-NH-PEG1-COOH TFA | 2140807-20-9 | Thalidomide-4-NH-PEG1-COOH TFA is a conjugate of E3 ligase ligand and linker consisting of Thalidomide and NH-PEG3-NH-Boc. | |
V82574 | Thalidomide-4-NH-PEG1-NH2 TFA | 2490499-21-1 | Thalidomide-4-NH-PEG1-NH2 TFA is an E3 ligase (e.g. CRBN) ligand-linker conjugate consisting of Thalidomide nd NH-PEG3-NH-Boc. | |
V82576 | Thalidomide-4-NH-PEG2-COO(t-Bu) | 2140807-16-3 | Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide, which could be utilized as Cereblon ligand to recruit CRBN protein. | |
V76438 | Thalidomide-4-O-C10-NH2 hydrochloride | Thalidomide-4-O-C10-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76437 | Thalidomide-4-O-C11-NH2 hydrochloride | Thalidomide-4-O-C11-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76436 | Thalidomide-4-O-C12-NH2 hydrochloride | Thalidomide-4-O-C12-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V81567 | Thalidomide-4-O-C13-NH2 hydrochloride | Thalidomide-4-O-C13-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76435 | Thalidomide-4-O-C14-NH2 hydrochloride | Thalidomide-4-O-C14-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76434 | Thalidomide-4-O-C7-NH2 hydrochloride | Thalidomide-4-O-C7-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN proteins. | ||
V81568 | Thalidomide-4-O-C9-NH2 hydrochloride | Thalidomide-4-O-C9-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V82549 | Thalidomide-5-methyl | 40313-92-6 | Thalidomide-5-methyl is a Thalidomide-based CRBN ligand used for CRBN protein recruitment. | |
V82522 | Thalidomide-5-NH-CH2-COO(t-Bu) | 2412056-28-9 | Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide , which could be utilized as Cereblon ligand to recruit CRBN protein. | |
V81569 | Thalidomide-5-NH-PEG5-NH2 hydrochloride | Thalidomide-5-NH-PEG5-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V78577 | Thalidomide-5-NH-PEG6-NH2 hydrochloride | Thalidomide-5-NH-PEG6-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76433 | Thalidomide-5-O-C10-NH2 hydrochloride | Thalidomide-5-O-C10-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76432 | Thalidomide-5-O-C11-NH2 hydrochloride | Thalidomide-5-O-C11-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76431 | Thalidomide-5-O-C12-NH2 hydrochloride | Thalidomide-5-O-C12-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76430 | Thalidomide-5-O-C13-NH2 hydrochloride | Thalidomide-5-O-C13-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76429 | Thalidomide-5-O-C14-NH2 hydrochloride | Thalidomide-5-O-C14-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. |