Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V99682	PLX-4545	2892065-45-9	PLX-4545 is an oral, cereblon-based IKZF2 (zinc finger transcription factor Helios) molecular glue degrader that reprograms immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses.
V84535	Pomalidomide 4'-alkylC6-azide	2375555-72-7
V84689	Pomalidomide 4'-alkylC8-acid	2305936-70-1
V84537	Pomalidomide 4'-PEG5-azide	2624181-61-7
V84337	Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride	2758431-94-4
V85170	Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride	2758431-93-3
V76613	Pomalidomide-5-C11-NH2 hydrochloride		Pomalidomide-5-C11-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V76612	Pomalidomide-5-C12-NH2 hydrochloride		Pomalidomide-5-C12-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V78713	Pomalidomide-5-C13-NH2 hydrochloride		Pomalidomide-5-C13-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V78537	Pomalidomide-5-C14-NH2 hydrochloride		Pomalidomide-5-C14-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V80120	Pomalidomide-5-C3-NH2 hydrochloride		Pomalidomide-5-C3-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V81170	Pomalidomide-5-C4-NH2 hydrochloride		Pomalidomide-5-C4-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V80004	Pomalidomide-5-C6-NH2 hydrochloride		Pomalidomide-5-C6-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V79810	Pomalidomide-5-C7-NH2 hydrochloride		Pomalidomide-5-C7-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82580	Pomalidomide-amino-PEG4-NH2 hydrochloride	2331259-45-9	Pomalidomide-amino-PEG4-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82547	Pomalidomide-C11-NH2	2648285-39-4	Pomalidomide-C11-NH2 is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82595	Pomalidomide-C5-Dovitinib	2732969-67-2	Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib linked to CRBN.
V85999	Pomalidomide-C6-COOH	2225940-50-9
V86279	Pomalidomide-CO-C5-azide	2227423-33-6
V81172	Pomalidomide-PEG7-NH2 hydrochloride		Pomalidomide-PEG7-NH2 HCl is a Pomalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.