Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V76428	Thalidomide-5-O-C7-NH2 hydrochloride		Thalidomide-5-O-C7-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76427	Thalidomide-5-O-C8-NH2 hydrochloride		Thalidomide-5-O-C8-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76426	Thalidomide-5-O-C9-NH2 hydrochloride		Thalidomide-5-O-C9-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82583	Thalidomide-5-PEG2-Cl	2230956-57-5	Thalidomide-5-PEG2-Cl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76425	Thalidomide-5-PEG6-NH2 hydrochloride		Thalidomide-5-PEG6-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76424	Thalidomide-5-PEG7-NH2 hydrochloride		Thalidomide-5-PEG7-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V69763	Thalidomide-NH-(CH2)2-NH2 TFA	1957235-67-4	Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified Thalidomide that can serve as Cereblon? ligand to recruit CRBN? protein.
V82585	Thalidomide-NH-amido-C2-NH2	2763827-10-5	Thalidomide-NH-amido-C2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82544	Thalidomide-NH-amido-C4-NH2	2093388-67-9	Thalidomide-NH-amido-C4-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V78714	Thalidomide-NH-C13-NH2 hydrochloride		Thalidomide-NH-C13-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76423	Thalidomide-NH-C14-NH2 hydrochloride		Thalidomide-NH-C14-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82525	Thalidomide-NH-PEG1-NH2	2138439-12-8	Thalidomide-NH-PEG1-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82589	Thalidomide-NH-PEG1-NH2 diTFA	2768514-19-6	Thalidomide-NH-PEG1-NH2 diTFA is a synthetic E3 ligase (e..g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V78578	Thalidomide-NH-PEG6-NH2 hydrochloride		Thalidomide-NH-PEG6-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82558	Thalidomide-O-C6-NHBoc	2509093-23-4	Thalidomide-O-C6-NHBoc is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82526	Thalidomide-O-PEG4-amine TFA	2934561-88-1	Thalidomide-O-PEG4-amine TFA is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V79920	Thalidomide-PEG3-NH2 hydrochloride		Thalidomide-PEG3-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V83751	Thalidomide-piperazine-(S)-CH2-pyrrolidine-C2-O-CH2-COO-C(CH3)3
V83802	Thalidomide-piperidine-O-azetidine-boc	2991611-55-1
V82545	Thiol-C9-PEG4	130727-41-2	Thiol-C9-PEG4 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.