A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V83803 | (S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid | ||
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V83735 | (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc | ||
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V83726 | (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc | ||
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V85210 | (S,R,S)-AHPC dihydrochloride (VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride) | 2137142-47-1 | |
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V4063 | (S,R,S)-AHPC hydrochloride | 1448189-80-7 | Protein degrader 1 HCl (hydrochloride) or PROTAC-VHL-ligandis a novel and potent small molecule ligand forVHL (Von Hippel-Lindau), which is anE3 ligasewhich has been targeted in many PROTAC (proteolysis-targeting chimeras) degraders. |
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V83764 | (S,R,S)-AHPC-acetyl-azetidine-PIP-boc | ||
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V83721 | (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc | ||
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V82564 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) | 2086301-47-3 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a ligand (for E3 ligase)-linker conjugate ( E3 ligase ligand-linker conjugate), containing VHL ligand. |
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V82555 | (S,R,S)-AHPC-C10-NHBoc | 2412055-13-9 | (S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC (HY -125845) VHL ligand and 1 linker. |
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V82542 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) | 2597167-24-1 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)- AHPC's VHL ligand and 4-unit PEG linker. (S,R,S)-AHPC-C2-PEG4-N3 may be utilized in the synthesis/preparation of vRucaparib-TP4 . |
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V83795 | (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH | ||
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V83777 | (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc | ||
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V83759 | (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc | ||
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V2400 | (S,R,S)-AHPC-Me | 1948273-02-6 | S,R,S)-AHPC-Me (also known as VHL ligand 2 or E3 ligase Ligand 1A) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
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V82543 | 4-Boc-amino-2,2-dimethylbutyric acid | 153039-17-9 | 4-Boc-amino-22-dimethylbutyric acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders. |
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V83736 | 4-Methylanisole-dihydrouracil-imidazo[1,2-a]pyridine-piperidine-NH-Boc | ||
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V82524 | 5-(Biotinamido)pentylazide | 1349190-76-6 | 5-Biotinamidopentylazide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain class, may be utilized to prepare PROTAC molecules. |
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V82556 | A 410099.1 amide-PEG2-amine-Boc | 2415256-16-3 | 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG2 linker with an amide terminal to bind to the target protein ligand. |
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V82534 | A 410099.1 amide-PEG3-amine-Boc | 2415256-19-6 | A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG3 linker with an amide at the end, which can bind to the target protein ligand. |
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V82535 | Acid-PEG2-ethyl propionate | 886362-90-9 | Acid-PEG2-ethyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |