A component of molecular glues is a protein degradation agent based on the ubiquitin-proteasome pathway. Small molecule substances known as "molecular glues" have the ability to stimulate or maintain protein binding. Molecular glue can cause another protein to undergo ubiquitin modification and destruction through the proteasome pathway, which is analogous to PROTAC, if one of the proteins is an ubiquitin ligase. However, in a later classification, these compounds are categorized as functional molecules that act as E3 ligase ligands. Thalidomide, lenalidomide, and pomalidomide, as well as the later-reported CC-90009 and CC-92480, are examples of older medications that fall into this group.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V82621 | 2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br | 2411022-24-5 | 2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br is a ligand (for E3 ligase)-linker conjugate used in the preparation /synthesis of PROTAC. | |
V85957 | Acetyl-cyclosporin A aldehyde | 121584-52-9 | ||
V87964 | CDO1 degrader-1 | CDO1 degrader-1 (compound 8) is a molecular glue degrader targeting cysteine dioxygenase (CDO1). | ||
V87956 | DS17 | DS17 is a molecular glue that acts as an effective degrader of cyclin K with an EC50 of 13 nM. | ||
V3568 | E7820 | 289483-69-8 | E7820 (E-7820) is a novel and potent angiogenesis inhibitor and α2 integrin inhibitor with anticancer activity. | |
V82620 | endo-BCN-PEG2-NH2 | 1263166-93-3 | endo-BCN-PEG2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V87960 | ER degrader 9 | 3023359-75-0 | ER degrader 9 (compound 1) is a bifunctional molecule and a potent estrogen receptor (ER) degrader with a DC50 of ≤10 nM in MCF-7 cells. | |
V87958 | GSPT1 degrader-4 | 3034764-32-1 | GSPT1 degrader-4 (3) is a molecular glue for GSPT1 (DC50 of 25.4 nM) with an IC50 value of 39 nM in CAL51 cells. | |
V87963 | GSPT1 degrader-5 | 3034764-38-7 | GSPT1 degrader-5 (4) is a molecular glue for GSPT1 (DC50 of 144 nM). | |
V87959 | GSPT1 degrader-6 | 3034764-41-2 | GSPT1 degrader-6 (8) is a molecular glue for GSPT1 (DC50 of 13 nM). | |
V87966 | HbF inducer 2 | 2654011-51-3 | HbF inducer 3 (Compound dWIZ-2) is an orally available molecular glue that degrades WIZ transcription factor (DC50=13 nM in primary human erythroid progenitor cells) and induces fetal hemoglobin (HbF) expression (EC50=100 nM). | |
V88888 | HuR degrader 2 | HuR degrader 2 (Compound 3) is a molecular glue that can target and degrade the RNA binding protein Hu antigen R (HuR), and can degrade 30% of HuR at 0.1 μM. | ||
V87961 | JWJ-01-306 | JWJ-01-306 is a molecular glue targeting the C2H2 zinc finger transcription factor ZBTB11. | ||
V87043 | KT-333 | 2502186-79-8 | KT-333 ammonium is a molecular glue that degrades STAT3 protein. | |
V87051 | KT-333 ammonium | 2839758-34-6 | KT-333 ammonium (compound A) is a molecular glue that degrades STAT3 protein. | |
V87044 | KT-333 diammonium | 2502186-80-1 | KT-333 diammonium is a molecular glue that degrades STAT3 protein. | |
V74602 | LSN3160440 | 2765539-59-9 | LSN3160440 is an allosteric modulator of GLP-1R and can serve as a stabilizer or molecular glue for protein-protein interactions (PPI) to assist inactive GLP-1 (9-36) NH2 to adhere to GLP-1R. | |
V82622 | Methyl-PEG4-acyl chloride | 62124-69-0 | Methyl-PEG4-acyl chloride is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V87085 | NST-628 | 3002056-30-3 | NST-628 is a MAPK pathway molecular glue with blood-brain barrier permeability and can inhibit RAF phosphorylation and MEK activation. | |
V86843 | Pan-RAS-IN-2 | 3034673-92-9 | Pan-RAS-IN-2 (compound 6A) is a molecular glue targeting RAS. |