PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82898	Biotin-PEG4-SH	2762393-22-4	Biotin-PEG4-SH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82860	Biotin-PEG6-NH-Boc	1292268-20-2	Biotin-PEG6-NH-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V78457	Biotin-PEG6-Silane		Biotin-PEG6-Silane is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V8152	Biotin-PEG7-amine	1334172-76-7	Biotin-PEG7-amine is PEG analogue containing a biotin group and a terminal primary amine group.
V78458	Biotin-PEG7-C2-NH-Vidarabine-S-CH3		Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG-like linker containing the adenosine analogue Vidarabine.
V78459	Biotin-PEG7-C2-S-Vidarabine		Biotin-PEG7-C2-S-Vidarabine is a PEG-like linker containing the adenosine analogue Vidarabine.
V78460	Biotin-PEG8-Vidarabine		Biotin-PEG8-Vidarabine is a PEG-like linker containing the adenosine analogue Vidarabine.
V82789	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA)	1205744-09-7	Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82943	Bis(2-bromoethyl) ether	5414-19-7	Bis2-bromoethyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl chain class, may be utilized to prepare PROTAC protein degraders.
V78474	Bis-(Mal-PEG3)-PH-N-succinimidyl acetate		Bis-(Mal-PEG3)-PH-N-succinimidyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82819	Bis-acrylate-PEG5	59256-52-9	Bis-acrylate-PEG5 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82718	Bis-acrylate-PEG6	85136-58-9	Bis-acrylate-PEG6 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82731	Bis-Mal-PEG6	2458811-07-7	Bis-Mal-PEG6 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82692	Bis-methacrylate-PEG5	13497-24-0	Bis-methacrylate-PEG5 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77196	Bis-PEG10-t-butyl ester		Bis-PEG10-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77745	Bis-PEG12-endo-BCN		Bis-PEG12-endo-BCN is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V78479	Bis-PEG18-Boc		Bis-PEG18-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82772	Bis-PEG2-Boc	1611468-28-0	Bis-PEG2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V82825	Bis-PEG25-TFP ester	2567199-52-2	Bis-PEG25-TFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82834	Bis-PEG3-t-butyl ester	1611468-29-1	Bis-PEG3-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.