PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82908	Bis-PEG4-TFP ester	1446282-42-3	Bis-PEG4-TFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V78481	Bis-PEG8-t-butyl ester		Bis-PEG8-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82964	Bis-sulfone-PEG4-DBCO	1854034-70-0	Bis-sulfone-PEG4-DBCO is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78482	Bis-sulfone-PEG4-Tetrazine		Bis-sulfone-PEG4-Tetrazine is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82753	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29)	2448704-23-0	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC (PROteolysis TArgeting Chimera) linker 29) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl ether class.
V82984	Boc-6-aminohexanoic acid	6404-29-1	Boc-6-aminohexanoic acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V82814	Boc-A 410099.1 amide-alkylC4-amine	2415256-18-5	Boc-A 410099.1 amide-alkylC4-amine is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-alkylC4 linker with an amide at the end, which can bind to the target protein ligand.
V82937	Boc-C2-NH2	15231-41-1	Boc-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V82737	Boc-HyNic-PEG1-mal	2743657-82-9	Boc-HyNic-PEG1-mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82915	Boc-NH-C4-Br	164365-88-2	Boc-NH-C4-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl chain category, may be utilized to prepare PROTAC protein degraders.
V80713	Boc-NH-PEG-Thiol (MW 10000)		Boc-NH-PEG-Thiol (MW 10000) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V80578	Boc-NH-PEG1-C5-OH		Boc-NH-PEG1-C5-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78517	Boc-NH-PEG11-C2-acid		Boc-NH-PEG11-C2-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78518	Boc-NH-PEG11-NHS ester		Boc-NH-PEG11-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77897	Boc-NH-PEG12-NH-Boc		Boc-NH-PEG12-NH-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78519	Boc-NH-PEG15-C1-acid		Boc-NH-PEG15-C1-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78520	Boc-NH-PEG15-C2-acid		Boc-NH-PEG15-C2-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78521	Boc-NH-PEG22-C2-NH2		Boc-NH-PEG22-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78522	Boc-NH-PEG26-C2-NH2		Boc-NH-PEG26-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82671	Boc-NH-PEG4-C2-Boc	2138484-13-4	Boc-NH-PEG4-C2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.