PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V78523 | Boc-NH-PEG5-Cl | Boc-NH-PEG5-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82832 | Boc-PEG1-Boc | 727729-33-1 | Boc-PEG1-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the alkyl/ether class, may be utilized to prepare PROTAC protein degraders. |
|
V79978 | Boc-PEG1-PPG2-C2-azido | Boc-PEG1-PPG2-C2-azido is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules. | |
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V78526 | Boc-PEG1-PPG2-C2-NH2 | Boc-PEG1-PPG2-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82843 | Boc-PEG2-ethoxyethane-PEG2-benzyl | 2111836-22-5 | Boc-PEG2-ethoxyethane-PEG2-benzyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V78527 | Boc-PEG25-benzyl | Boc-PEG25-benzyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82865 | Boc-PEG4-methyl propionate | 2100306-74-7 | Boc-PEG4-methyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82977 | Boc-piperazine-benzoic acid | 162046-66-4 | Boc-piperazine-benzoic acid is a PROTAC (PROteolysis TArgeting Chimera) linker that may be utilized to prepare PROTACs such as the androgen receptor (AR) degrader ARD-2128 . |
|
V80452 | Boc-Pyrrolidine-PEG2-COOH | Boc-Pyrrolidine-PEG2-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
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V82883 | BocNH-PEG5-CH2CH2Br | 1392499-33-0 | BocNH-PEG5-CH2CH2Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82691 | Br-Boc-C2-azido | 1120364-53-5 | Br-Boc-C2-azido is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the alkyl/ether category, may be utilized to prepare PROTAC molecules. |
|
V82971 | Br-C3-methyl ester | 4897-84-1 | Br-C3-methyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC PD-1/PD-L1 degrader-1 . |
|
V77418 | Br-PEG2-oxazolidin-2-one | Br-PEG2-oxazolidin-2-one is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V78562 | Br-PEG3-MS | Br-PEG3-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
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V80397 | Br-PEG4-acid | Br-PEG4-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82854 | Br-PEG6-C2-acid | 309916-91-4 | Br-PEG6-C2-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82724 | Br-PEG6-CH2COOtBu | 297162-48-2 | Br-PEG6-CH2COOtBu is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |
|
V78563 | Br-PEG7-NHBoc | Br-PEG7-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V78564 | Br-PEG9-C2-NHBoc | Br-PEG9-C2-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V82847 | Brigatinib C | 1197958-75-0 | Brigatinib C is the linker portion of HJM-561 assembled into PROTAC. |
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